FYN phosphorylates PAK2

Stable Identifier
R-HSA-5218812
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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FYN phosphorylates PAK2
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PAK2 activity via GTPases can be strongly potentiated by concurrent stimulation of cellular tyrosine kinase activity. FYN may be involved in this potentiation by phosphorylating Y130 in the N-terminal regulatory domain leading to a robust enhancement of the catalytic activity of PAK2 (Renkema et al. 2002).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane]

Physical Entity
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
FYN phosphorylates PAK2 (Bos taurus)
FYN phosphorylates PAK2 (Caenorhabditis elegans)
FYN phosphorylates PAK2 (Canis familiaris)
FYN phosphorylates PAK2 (Danio rerio)
FYN phosphorylates PAK2 (Drosophila melanogaster)
FYN phosphorylates PAK2 (Gallus gallus)
FYN phosphorylates PAK2 (Mus musculus)
FYN phosphorylates PAK2 (Rattus norvegicus)
FYN phosphorylates PAK2 (Sus scrofa)
FYN phosphorylates PAK2 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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