CRK binds BCAR1 and or PXN

Stable Identifier
R-HSA-5218822
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CRK (CT10 Regulator of Kinase) is composed of one SH2 and one or two SH3 domains. This adaptor protein binds with phosphorylated tyrosine motifs found in proteins involved in cell spreading, actin reorganisation, and cell migration. Paxillin (PAX) and p130CAS are the two major focal adhesion components that binds with CRK to form multiprotein signaling complexes and regulate cell migration (Klemke et al. 1998, Valles et al. 2004, Lamorte et al. 2003).

Literature References
PubMed ID Title Journal Year
15308668 Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells

Vall├ęs, AM, Beuvin, M, Boyer, B

J. Biol. Chem. 2004
9472046 CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

Klemke, RL, Leng, J, Molander, R, Brooks, PC, Vuori, K, Cheresh, DA

J. Cell Biol. 1998
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