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p-6Y-VEGFR2 binds FYN
Stable Identifier
R-HSA-5218824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
p-6Y-VEGFR2 binds FYN (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Tyrosine-1214 phosphorylation allows recruitment of cytoplasmic tyrosine kinase FYN along with NCK to VEGFR2. FYN and NCK associate with each other. This complex mediates phosphorylation of p21-activated protein kinase 2 (PAK2) and subsequent activation of p38MAPK mediating actin reorganization and cell migration (Lamalice et al. 2006).
Literature References
PubMed ID
Title
Journal
Year
16966330
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
Houle, F
,
Huot, J
,
Lamalice, L
J. Biol. Chem.
2006
Participants
Input
FYN [cytosol]
(Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane]
(Homo sapiens)
Output
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane]
(Homo sapiens)
Participates
as an event of
VEGFA-VEGFR2 Pathway (Homo sapiens)
Orthologous Events
p-6Y-VEGFR2 binds FYN (Bos taurus)
p-6Y-VEGFR2 binds FYN (Canis familiaris)
p-6Y-VEGFR2 binds FYN (Danio rerio)
p-6Y-VEGFR2 binds FYN (Gallus gallus)
p-6Y-VEGFR2 binds FYN (Mus musculus)
p-6Y-VEGFR2 binds FYN (Rattus norvegicus)
p-6Y-VEGFR2 binds FYN (Sus scrofa)
p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)
Authored
Garapati, P V (2013-08-30)
Reviewed
Ballmer-Hofer, K (2014-05-12)
Welsh, M (2014-05-12)
Berger, P (2014-05-12)
Created
Garapati, P V (2013-12-19)
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