SRC-1 phosphorylates PTK2-beta

Stable Identifier
R-HSA-5218830
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Proline tyrosine kinase 2-beta (PTK2B/PYK2) is rapidly tyrosine phosphorylated on Y402 through Src-kinases in response to ligation of integrin beta3.

Literature References
PubMed ID Title Journal Year
15695828 Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2

Butler, B, Blystone, SD

J. Biol. Chem. 2005
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane]

Orthologous Events
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