TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine

Stable Identifier
R-HSA-5220952
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from mouse, TET1, TET2, and TET3 each oxidize 5-formylcytosine (5-fC) in DNA using molecular oxygen and 2-oxoglutarate to yield 5-carboxylcytosine (5-caC).

Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
methylcytosine dioxygenase activity of TET1,2,3 [nucleoplasm]
Physical Entity
Activity
Inferred From
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Reviewed
Created