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TET2 [nucleoplasm]
Stable Identifier
R-HSA-5221011
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Methylcytosine dioxygenase TET2 ecNumber1.14.11.n2/ecNumber, TET2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
TET1,2,3 and TDG demethylate DNA (Homo sapiens)
TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine (Homo sapiens)
TET1,2,3 [nucleoplasm] (Homo sapiens)
TET2:Fe2+ [nucleoplasm] (Homo sapiens)
TET2 [nucleoplasm] (Homo sapiens)
TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Homo sapiens)
TET1,2,3 [nucleoplasm] (Homo sapiens)
TET2:Fe2+ [nucleoplasm] (Homo sapiens)
TET2 [nucleoplasm] (Homo sapiens)
TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (Homo sapiens)
TET1,2,3 [nucleoplasm] (Homo sapiens)
TET2:Fe2+ [nucleoplasm] (Homo sapiens)
TET2 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Specification of primordial germ cells (Homo sapiens)
Expression of TET2 in primordial germ cells (Homo sapiens)
TET2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6N021 TET2
Gene Names
TET2, KIAA1546, Nbla00191
Chain
chain:1-2002
Reference Genes
COSMIC (genes):TET2 TET2
dbSNP Gene:54790 TET2
ENSEMBL:ENSG00000168769 TET2
Participates
as an output of
Expression of TET2 in primordial germ cells (Homo sapiens)
as a component of
TET2:Fe2+ [nucleoplasm] (Homo sapiens)
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.68
4
UniProt:O15294 OGT
2
OGT [nucleoplasm]
(R-HSA-3321845)
OGT [cytosol]
(R-HSA-9687814)
0.659
7
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.615
3
UniProt:Q15233 NONO
0.615
4
UniProt:P19544 WT1
1
WT1 [nucleoplasm]
(R-HSA-452420)
0.602
9
UniProt:P04279 SEMG1
2
SEMG1 [extracellular region]
(R-HSA-977100)
hC239-SEMG1 [extracellular region]
(R-HSA-6810688)
0.589
2
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
0.556
3
UniProt:P06396 GSN
7
GSN [cytosol]
(R-HSA-350275)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
0.556
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.483
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.483
2
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