ABCE1 binds RNASEL, inhibiting it

Stable Identifier
R-HSA-5223305
Type
Reaction [binding]
Species
Homo sapiens
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2-5A-dependent ribonuclease (RNASEL) is an endoribonuclease that is activated in the interferon (IFN) antiviral response. Its anti-viral effects are probably a combination of induction of apoptosis, cleavage of viral mRNA and induction of other anti-viral genes. ATP-binding cassette sub-family E member 1 (ABCE1, aka RNase L inhibitor, RLI) directly interacts with RNASEL and inhibits its endoribonuclease activity, thus antagonising the anti-viral effect of the IFN-regulated 2-5A/RNase L pathway (Martinand et al. 1998, Martinand et al. 1999, Le Roy et al. 2001).

Literature References
PubMed ID Title Journal Year
11585831 The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells

Le Roy, F, Bisbal, C, Silhol, M, Martinand, C, Lebleu, B, Salehzada, T

J. Biol. Chem. 2001
9660177 RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells

Martinand, C, Salehzada, T, Silhol, M, Lebleu, B, Bisbal, C

Eur. J. Biochem. 1998
9847332 RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells

Martinand, C, Montavon, C, Salehzada, T, Silhol, M, Lebleu, B, Bisbal, C

J. Virol. 1999
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