Reactome | RBBP7 binds histone H3

RBBP7 binds histone H3

Stable Identifier

R-HSA-5225649

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RBBP7, a central component of the co-repressor complexes Sin3a, NURD and PRC2, can bind histone H3 arginine-3 (H3R2). Symmetrical dimethylation of this residue excludes RBBP7 binding but enhances binding of WDR5, a common component of the coactivator complexes MLL, SET1A, SET1B, NLS1 and ATAC (Migliori et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22231400	Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance Guccione, E, Cecatiello, V, Sahu, SK, Mapelli, M, Bezzi, M, Bassi, C, Migliori, V, Capasso, P, Low, D, Müller, J, Kuznetsov, V, De Marco, A, Blackstock, W, Gunaratne, J, Mok, WC, Phalke, S, Amati, B	Nat. Struct. Mol. Biol.	2012