tetX HC transports tetX LC from target cell endosome membrane into cytosol

Stable Identifier
R-HSA-5228406
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Clostridium tetani
Compartment
cytosol, endocytic vesicle membrane
ReviewStatus
5/5
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tetX HC transports tetX LC from target cell endosome membrane into cytosol
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Acidification of the vesicle containing tetanus toxin disulfide-bonded heavy chain - light chain dimer (tetX HC:LC) is inferred to cause a conformational change in the toxin dimer, allowing the HC part of the toxin to function as a channel through which its LC part is extruded into the neuronal cytosol (Montal 2010).
Literature References
PubMed ID Title Journal Year
20233039 Botulinum neurotoxin: a marvel of protein design

Montal, M

Annu. Rev. Biochem. 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein transmembrane transporter activity of tetX:gangliosides [endocytic vesicle membrane]

Physical Entity
tetX:gangliosides [endocytic vesicle membrane] (Clostridium tetani)
Activity
protein transmembrane transporter activity (GO:0008320)
This event is regulated
Positively by
Regulator
H+ [endocytic vesicle lumen]
Disease
Name Identifier Synonyms
tetanus DOID:11338 clostridial tetanus, Tetanus (disorder), Infection due to Clostridium tetani (disorder)
Authored
D'Eustachio, P  (2014-02-11)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-11)
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