tetX HC:LC binds target cell-surface gangliosides

Stable Identifier
R-HSA-5228407
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Clostridium tetani
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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tetX HC:LC binds target cell-surface gangliosides
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Tetanus toxin disulfide-bonded heavy chain - light chain dimer (tetX HC:LC) binds gangliosides on the plasma membrane of a human target cell (Chen et al. 2009; Deinhardt et al. 2006).
Literature References
PubMed ID Title Journal Year
16880274 Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1

Deinhardt, K, Berninghausen, O, Willison, HJ, Hopkins, CR, Schiavo, G

J. Cell Biol. 2006
19602728 Gangliosides as high affinity receptors for tetanus neurotoxin

Chen, C, Fu, Z, Kim, JJ, Barbieri, JT, Baldwin, MR

J. Biol. Chem. 2009
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tetanus DOID:11338 clostridial tetanus, Tetanus (disorder), Infection due to Clostridium tetani (disorder)
Cross References
Mondo
Authored
D'Eustachio, P  (2014-02-11)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-11)
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