tetX HC:LC binds target cell-surface gangliosides

Stable Identifier
R-HSA-5228407
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Clostridium tetani
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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tetX HC:LC binds target cell-surface gangliosides
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Tetanus toxin disulfide-bonded heavy chain - light chain dimer (tetX HC:LC) binds gangliosides on the plasma membrane of a human target cell (Chen et al. 2009; Deinhardt et al. 2006).
Literature References
PubMed ID Title Journal Year
16880274 Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1

Schiavo, G, Hopkins, CR, Deinhardt, K, Willison, HJ, Berninghausen, O

J. Cell Biol. 2006
19602728 Gangliosides as high affinity receptors for tetanus neurotoxin

Baldwin, MR, Barbieri, JT, Chen, C, Kim, JJ, Fu, Z

J. Biol. Chem. 2009
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tetanus DOID:11338 clostridial tetanus, Tetanus (disorder), Infection due to Clostridium tetani (disorder)
Authored
D'Eustachio, P  (2014-02-11)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-11)
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