Reactome: A Curated Pathway Database

RANBP2 SUMOylates PML with SUMO1

Stable Identifier
R-HSA-5228508
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RANBP2 of the nuclear pore complex SUMOylates PML with SUMO1 at lysine-65, lysine-160, and lysine-490 (Sternsdorf et al. 1997, Kamitani et al. 1998, Duprez et al. 1999). SUMOylated PML is observed during interphase but not during mitosis (Everett et al. 1999). RANBP2 contains both a binding site for SUMO1 and a binding site for UBE2I (Tatham et al. 2005). The binding site for SUMO1 may play a role in SUMOylation of PML with SUMO1. Knockdown of RANBP2 reduces the number of PML bodies (Saitoh et al. 2006).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope] Nuclear Pore Complex (NPC) [nuclear envelope] SUMO transferase activity (0019789)
Orthologous Events