RANBP2 SUMOylates MDM2 with SUMO1

Stable Identifier
R-HSA-5228523
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO1 to MDM2
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RANBP2 of the nuclear pore complex SUMOylates MDM2 with SUMO1 at lysine-182 (Mayauchi et al. 2002). An unSUMOylatable mutant of MDM2 accumulates in the cytosol so SUMOylation may be part of the process of nuclear import of MDM2 (Miyauchi et al. 2002).

Literature References
PubMed ID Title Journal Year
12393906 Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes

Miyauchi, Y, Yogosawa, S, Honda, R, Nishida, T, Yasuda, H

J. Biol. Chem. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created