RANBP2 SUMOylates MDM2 with SUMO1

Stable Identifier
R-HSA-5228523
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, nuclear envelope
Synonyms
Conjugation of SUMO1 to MDM2
ReviewStatus
5/5
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RANBP2 SUMOylates MDM2 with SUMO1
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RANBP2 of the nuclear pore complex SUMOylates MDM2 with SUMO1 at lysine-182 (Mayauchi et al. 2002). An unSUMOylatable mutant of MDM2 accumulates in the cytosol so SUMOylation may be part of the process of nuclear import of MDM2 (Miyauchi et al. 2002).
Literature References
PubMed ID Title Journal Year
12393906 Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes

Honda, R, Miyauchi, Y, Nishida, T, Yogosawa, S, Yasuda, H

J. Biol. Chem. 2002
Participants
Input
Output
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as an event of
Catalyst Activity

SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Physical Entity
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
RANBP2 SUMOylates MDM2 with SUMO1 (Bos taurus)
RANBP2 SUMOylates MDM2 with SUMO1 (Gallus gallus)
RANBP2 SUMOylates MDM2 with SUMO1 (Mus musculus)
RANBP2 SUMOylates MDM2 with SUMO1 (Rattus norvegicus)
RANBP2 SUMOylates MDM2 with SUMO1 (Sus scrofa)
RANBP2 SUMOylates MDM2 with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-01-24)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2014-01-14)
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