tetX LC cleaves target cell VAMP2

Stable Identifier
R-HSA-5228578
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Clostridium tetani
Compartment
endocytic vesicle membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
tetX LC cleaves target cell VAMP2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Tetanus toxin light chain (tetX LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from vesicle-associated membrane protein 2 (VAMP2). tetX LC is a zinc metalloprotease (Foran et al. 1994; Schiavo et al. 1992). VAMP2 is associated with the cytosolic face of the target cell synaptic vesicle and is required for vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks exocytosis and in vivo leads to a long-lasting spastic paralysis (Link et al. 1992).
Literature References
PubMed ID Title Journal Year
1361727 Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis

Link, E, Edelmann, L, Chou, JH, Binz, T, Yamasaki, S, Eisel, U, Baumert, M, Südhof, TC, Niemann, H, Jahn, R

Biochem. Biophys. Res. Commun. 1992
7803399 Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments

Foran, P, Shone, CC, Dolly, JO

Biochemistry 1994
1396558 Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc

Schiavo, G, Poulain, B, Rossetto, O, Benfenati, F, Tauc, L, Montecucco, C

EMBO J. 1992
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of tetX LC:Zn2+ [cytosol]

Physical Entity
tetX LC:Zn2+ [cytosol] (Clostridium tetani)
Activity
metalloendopeptidase activity (GO:0004222)
Disease
Name Identifier Synonyms
tetanus DOID:11338 clostridial tetanus, Tetanus (disorder), Infection due to Clostridium tetani (disorder)
Cross References
Mondo
Authored
D'Eustachio, P  (2014-02-11)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-14)
Cite Us!