TeNT LC cleaves target cell VAMP2

Stable Identifier
R-HSA-5228578
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Clostridium tetani
Compartment
endocytic vesicle membrane, cytosol
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TeNT LC cleaves target cell VAMP2
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Tetanus toxin light chain (TeNT LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from vesicle-associated membrane protein 2 (VAMP2). TeNT LC is a zinc metalloprotease (Foran et al. 1994; Schiavo et al. 1992). VAMP2 is associated with the cytosolic face of the target cell synaptic vesicle and is required for vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks exocytosis and in vivo leads to a long-lasting spastic paralysis (Link et al. 1992).

Literature References
PubMed ID Title Journal Year
7803399 Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments

Foran, P, Shone, CC, Dolly, JO

Biochemistry 1994
1361727 Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis

Link, E, Edelmann, L, Chou, JH, Binz, T, Yamasaki, S, Eisel, U, Baumert, M, Südhof, TC, Niemann, H, Jahn, R

Biochem. Biophys. Res. Commun. 1992
1396558 Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc

Schiavo, G, Poulain, B, Rossetto, O, Benfenati, F, Tauc, L, Montecucco, C

EMBO J. 1992
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of TeNT LC:Zn2+ [cytosol]
Physical Entity
TeNT LC:Zn2+ [cytosol]
Activity
metalloendopeptidase activity (0004222)
Disease
Name Identifier Synonyms
tetanus 11338 clostridial tetanus, Tetanus (disorder), Infection due to Clostridium tetani (disorder)
Authored
D'Eustachio, P  (2014-02-11)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-14)