Reactome | p-S23, S395, S405-LMNB1 [nucleoplasm]

p-S23, S395, S405-LMNB1 [nucleoplasm]

Stable Identifier

R-HSA-5229018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P20700 LMNB1

Gene Names

LMNB1, LMN2, LMNB

Chain

initiator methionine:1, chain:2-583, propeptide:584-586

Reference Genes

BioGPS Gene:4001 LMNB1

COSMIC (genes):LMNB1 LMNB1

CTD Gene:4001 LMNB1

dbSNP Gene:4001 LMNB1

ENSEMBL:ENSG00000113368 LMNB1

HGNC:6637 LMNB1

KEGG Gene (Homo sapiens):4001 LMNB1

Monarch:4001 LMNB1

NCBI Gene:4001 LMNB1

OMIM:150340 LMNB1

UCSC:P20700 LMNB1

Reference Transcript

RefSeq:NM_005573.3 LMNB1

Other Identifiers

11732533_a_at

11744888_a_at

11744889_a_at

11750441_a_at

11750442_s_at

16988703

203276_at

2827186

2827187

2827188

2827189

2827192

2827193

2827195

2827196

2827199

2827202

2827203

2827204

2827205

2827207

2827208

2827209

2827210

2KPW

37985_at

3JT0

3TYY

3UMN

4001

50524

5269

53579

5VVX

8107706

A0A0D9SFE5

A0A0D9SFY5

A_14_P108109

A_23_P258493

AAA36162

AAC37575

AAH12295

AAI03724

AK312603

BAG35493

BC012295

BC103723

CAB005269

CCDS4140

CH471086

E9PBF6

EAW48846

ENSG00000113368

ENSP00000261366

ENST00000261366

ENST00000261366.9

EntrezGene:4001

EntrezGene:LMNB1

g5031876_3p_at

g5031876_3p_x_at

GO:0003674

GO:0003677

GO:0003690

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005637

GO:0005638

GO:0005654

GO:0005856

GO:0005882

GO:0007165

GO:0008150

GO:0016020

GO:0016363

GO:0019899

GO:0031965

GO:0035722

GO:0043226

GO:0043274

GO:1990837

HGNC:6637

HPA050524

HPA053579

ILMN_1672988

IPR001322

IPR018039

IPR036415

IPR039008

IPR042180

L37737

L37738

L37739

L37740

L37741

L37742

L37743

L37744

L37745

L37746

L37747

LMNB1

LMNB1-201

M34458

M34458_rna1_s_at

MIM:150340

MIM:169500

NM_001198557

NM_005573

NP_001185486

NP_005564

PF00038

PF00932

PH_hs_0004988

PH_hs_0040083

SM01391

TC05000604.hg

UPI000013D170

Participant Of

hasComponent

p-S23, S395, S405-Lamin B1 dimer [nucleoplasm]

Other forms of this molecule

LMNB1 [nucleoplasm]

p-S395, S405-LMNB1 [nucleoplasm]

LMNB1 [cytosol]

LMNB1(1-231) [nuclear envelope]

LMNB1(232-586) [nuclear envelope]

LMNB1(2-586) [nuclear envelope]

p-S23,S393-LMNB1 [nucleoplasm]

Inferred To

phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Bos taurus)

phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Canis familiaris)

phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Danio rerio)

phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Mus musculus)

phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Rattus norvegicus)

phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Sus scrofa)

phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 23

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 395

Coordinate

395

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 405

Coordinate

405

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_005564.1

OpenTargets

ENSG00000113368

GeneCards

P20700

PRO

P20700

Orphanet

16365

PDB

3JT0, 3UMN, 5VVX, 3TYY, 2KPW

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537) LMNA(1-664) [nucleoplasm] (R-HSA-535479)	0.813	9
UniProt:Q03252 LMNB2			0.721	4
UniProt:P02545-1 LMNA	7	LMNA(231-664) [nuclear envelope] (R-HSA-352249) p-S22, S392-LMNA-1 [nucleoplasm] (R-HSA-8868349) LMNA(1-230) [nuclear envelope] (R-HSA-352253) Lamin A [nucleoplasm] (R-HSA-264866) p-S395-LMNA-1 [nucleoplasm] (R-HSA-5228743) p-S22, S395-LMNA-1 [nucleoplasm] (R-HSA-5229021) LMNA-1 [cytosol] (R-HSA-2995371)	0.677	5
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674)	0.675	14
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.623	4
UniProt:P52294 KPNA1	2	KPNA1 [nucleoplasm] (R-HSA-188865) KPNA1 [cytosol] (R-HSA-180612)	0.621	3
UniProt:P02545-2 LMNA	5	Lamin C [nucleoplasm] (R-HSA-264872) LMNA-2 [nuclear envelope] (R-HSA-912378) p-S395-LMNA-2 [nucleoplasm] (R-HSA-5228740) p-S22, S395-LMNA-2 [nucleoplasm] (R-HSA-5229019) LMNA-2 [cytosol] (R-HSA-2995387)	0.601	19
UniProt:Q05322 VP24			0.499	6
UniProt:P36956-PRO_0000314029 SREBF1			0.489	2
IntAct:EBI-11985505 KPNA5			0.488	2
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.488	2
UniProt:O95295 SNAPIN	2	SNAPIN [cytoplasmic vesicle membrane] (R-HSA-434204) SNAPIN [Golgi membrane] (R-HSA-434344)	0.488	2
UniProt:A6NC98 CC88B			0.488	2
UniProt:Q9H3R5 CENPH	2	CENPH [cytosol] (R-HSA-375294) CENPH [nucleoplasm] (R-HSA-606314)	0.488	2
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.488	2
UniProt:Q7KZS0 Q7KZS0			0.488	2
UniProt:Q8WWB5 PIHD2			0.488	4
UniProt:O60684 IMA7			0.488	2
UniProt:Q05BL1 Q05BL1			0.488	2
UniProt:Q9Y6X4 F169A			0.488	2
UniProt:Q8TC57 M1AP			0.488	2