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p-S23, S395, S405-LMNB1 [nucleoplasm]
Stable Identifier
R-HSA-5229018
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Depolymerisation of the Nuclear Lamina (Homo sapiens)
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Homo sapiens)
p-S22/23, S395-Lamin dimers [nucleoplasm] (Homo sapiens)
p-S23, S395, S405-Lamin B1 dimer [nucleoplasm] (Homo sapiens)
p-S23, S395, S405-LMNB1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20700 LMNB1
Gene Names
LMNB1, LMN2, LMNB
Chain
initiator methionine:1, chain:2-583, propeptide:584-586
Reference Genes
BioGPS Gene:4001 LMNB1
COSMIC (genes):LMNB1 LMNB1
CTD Gene:4001 LMNB1
dbSNP Gene:4001 LMNB1
ENSEMBL:ENSG00000113368 LMNB1
HGNC:6637 LMNB1
KEGG Gene (Homo sapiens):4001 LMNB1
Monarch:4001 LMNB1
NCBI Gene:4001 LMNB1
OMIM:150340 LMNB1
UCSC:P20700 LMNB1
Reference Transcript
RefSeq:NM_005573.3 LMNB1
Other Identifiers
11732533_a_at
11744888_a_at
11744889_a_at
11750441_a_at
11750442_s_at
16988703
203276_at
2827186
2827187
2827188
2827189
2827192
2827193
2827195
2827196
2827199
2827202
2827203
2827204
2827205
2827207
2827208
2827209
2827210
37985_at
4001
8107706
A_14_P108109
A_23_P258493
GO:0003674
GO:0003677
GO:0003690
GO:0005198
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005637
GO:0005638
GO:0005654
GO:0005856
GO:0005882
GO:0007165
GO:0008150
GO:0016020
GO:0016363
GO:0019899
GO:0031965
GO:0035722
GO:0043226
GO:0043274
GO:1990837
ILMN_1672988
M34458_rna1_s_at
PH_hs_0004988
PH_hs_0040083
TC05000604.hg
g5031876_3p_at
g5031876_3p_x_at
Participant Of
hasComponent
p-S23, S395, S405-Lamin B1 dimer [nucleoplasm]
Other forms of this molecule
LMNB1 [cytosol]
LMNB1 [nucleoplasm]
p-S395, S405-LMNB1 [nucleoplasm]
LMNB1(1-231) [nuclear envelope]
LMNB1(232-586) [nuclear envelope]
LMNB1(2-586) [nuclear envelope]
p-S23,S393-LMNB1 [nucleoplasm]
Inferred To
phospho-Lmnb1 [nucleoplasm] (Mus musculus)
phospho-Lmnb1 [nucleoplasm] (Rattus norvegicus)
phospho-LMNB1 [nucleoplasm] (Bos taurus)
phospho-LMNB1 [nucleoplasm] (Canis familiaris)
phospho-LMNB1 [nucleoplasm] (Gallus gallus)
phospho-lmn-1 [nucleoplasm] (Caenorhabditis elegans)
phospho-lmnb1 [nucleoplasm] (Danio rerio)
phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Sus scrofa)
phospho-p-S23, S395, S405-LMNB1 [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 23
Coordinate
23
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 395
Coordinate
395
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 405
Coordinate
405
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_005564.1
OpenTargets
ENSG00000113368
HPA
ENSG00000113368-LMNB1
GeneCards
P20700
Ensembl
ENST00000261366
,
ENSG00000113368
,
ENSP00000261366
PRO
P20700
Orphanet
16365
PDB
5VVX
,
3TYY
,
2KPW
,
3JT0
,
3UMN
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02545 LMNA
3
LMNA-RAF1 fusion [cytosol]
(R-HSA-6802399)
LMNA(1-664) [nucleoplasm]
(R-HSA-535479)
p-LMNA-RAF1 fusion [cytosol]
(R-HSA-6802537)
0.86
10
UniProt:Q03252 LMNB2
0.75
5
UniProt:P02545-1 LMNA
7
LMNA(231-664) [nuclear envelope]
(R-HSA-352249)
p-S22, S392-LMNA-1 [nucleoplasm]
(R-HSA-8868349)
LMNA(1-230) [nuclear envelope]
(R-HSA-352253)
p-S22, S395-LMNA-1 [nucleoplasm]
(R-HSA-5229021)
p-S395-LMNA-1 [nucleoplasm]
(R-HSA-5228743)
Lamin A [nucleoplasm]
(R-HSA-264866)
LMNA-1 [cytosol]
(R-HSA-2995371)
0.677
5
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
0.675
14
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.666
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.623
4
UniProt:P02545-2 LMNA
5
p-S22, S395-LMNA-2 [nucleoplasm]
(R-HSA-5229019)
LMNA-2 [nuclear envelope]
(R-HSA-912378)
p-S395-LMNA-2 [nucleoplasm]
(R-HSA-5228740)
Lamin C [nucleoplasm]
(R-HSA-264872)
LMNA-2 [cytosol]
(R-HSA-2995387)
0.601
19
UniProt:O95295 SNAPIN
2
SNAPIN [cytoplasmic vesicle membrane]
(R-HSA-434204)
SNAPIN [Golgi membrane]
(R-HSA-434344)
0.556
3
UniProt:Q9NPF5 DMAP1
1
DMAP1 [nucleoplasm]
(R-HSA-212166)
0.556
3
UniProt:A6NC98 CC88B
0.556
3
UniProt:Q9H3R5 CENPH
2
CENPH [cytosol]
(R-HSA-375294)
CENPH [nucleoplasm]
(R-HSA-606314)
0.556
3
UniProt:Q96KQ4 PPP1R13B
1
PPP1R13B [nucleoplasm]
(R-HSA-6799775)
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:Q8WWB5 PIHD2
0.556
3
IntAct:EBI-22370853 CCSB ORF ID
0.556
3
UniProt:Q8TC57 M1AP
0.556
3
UniProt:Q9Y6X4 F169A
0.556
3
UniProt:O60684 IMA7
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q05322 VP24
0.499
6
UniProt:P36956-PRO_0000314029 SREBF1
0.489
2
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