ARV1 transports CHOL from ER membrane to plasma membrane

Stable Identifier
R-HSA-5250531
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sterols such as cholesterol (CHOL) synthesised in the endoplasmic reticulum (ER) need to be efficiently transported to the plasma membrane, where 90% of the free sterol pool resides. Conversely, sterols taken up from outside the cell need to be transported back to the ER for esterification to sterol esters. The mechanisms that control this bi-directional movement of sterols are still poorly understood but a likely candidate is protein ARV1 (ARV1). Studies with mutant yeast Arv1 indicate altered intracellular sterol distribution and subsequent defects in sphingolipid metabolism. Human ARV1, a predicted sequence ortholog of yeast Arv1, complements the defects seen associated with deletion of yeast Arv1 (Tinkelenberg et al. 2000, Swain et al. 2002).

Literature References
PubMed ID Title Journal Year
11063737 Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1

Tinkelenberg, AH, Liu, Y, Alcantara, F, Khan, S, Guo, Z, Bard, M, Sturley, SL

J. Biol. Chem. 2000
12145310 Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1

Swain, E, Stukey, J, McDonough, V, Germann, M, Liu, Y, Sturley, SL, Nickels, JT

J. Biol. Chem. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sterol transporter activity of ARV1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created