Reactome | DDX21 [nucleoplasm]

DDX21 [nucleoplasm]

Stable Identifier

R-HSA-5250652

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nucleolar RNA helicase 2 ecNumber3.6.4.13/ecNumber, DDX21_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:P05412 JUN

Expand all

External Reference Information

External Reference

UniProt:Q9NR30 DDX21

Gene Names

DDX21

Chain

chain:1-783

Reference Genes

BioGPS Gene:9188 DDX21

COSMIC (genes):DDX21 DDX21

CTD Gene:9188 DDX21

dbSNP Gene:9188 DDX21

ENSEMBL:ENSG00000165732 DDX21

ENSEMBL:ENSG00000165732.14 DDX21

HGNC:2744 DDX21

KEGG Gene (Homo sapiens):9188 DDX21

Monarch:9188 DDX21

NCBI Gene:9188 DDX21

OMIM:606357 DDX21

UCSC:Q9NR30 DDX21

Reference Transcript

Other Identifiers

11733073_a_at

11756223_s_at

11759622_s_at

16705474

208152_PM_s_at

208152_s_at

224654_PM_at

224654_at

3250059

3250060

3250061

3250062

3250063

3250064

3250065

3250066

3250067

3250068

3250069

3250070

3250071

3250072

3250074

3250075

3250076

3250078

3250079

3250081

3250082

3250083

3250084

3250086

3250089

3250090

3250091

3250092

40490_at

65890_at

7927936

9188

A_14_P112663

A_24_P146603

A_24_P415260

A_33_P3287815

GE81435

GE88016

GO:0000166

GO:0001649

GO:0002376

GO:0002735

GO:0003676

GO:0003723

GO:0003724

GO:0003725

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0006260

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006364

GO:0006366

GO:0009615

GO:0016020

GO:0016787

GO:0016887

GO:0019843

GO:0023052

GO:0030154

GO:0030515

GO:0035066

GO:0035198

GO:0036211

GO:0042254

GO:0042802

GO:0043123

GO:0043226

GO:0043330

GO:0045087

GO:0045943

GO:0045944

GO:0045945

GO:0051607

GO:0062176

GO:0097322

GO:0098542

GO:0110016

GO:0140098

GO:0140657

HMNXSV003031096

Hs.5122.0.S1_3p_at

ILMN_1735461

PH_hs_0010109

PH_hs_0032217

TC10000413.hg

TC10002105.hg

U41387_at

g13787208_3p_s_at

Participates

as a component of

as an input of

B-WICH complex binds rDNA promoter (Homo sapiens)

Inferred To

DDX21 [nucleoplasm] (Bos taurus)

DDX21 [nucleoplasm] (Canis familiaris)

DDX21 [nucleoplasm] (Gallus gallus)

DDX21 [nucleoplasm] (Mus musculus)

DDX21 [nucleoplasm] (Rattus norvegicus)

DDX21 [nucleoplasm] (Sus scrofa)

cb960 [nucleoplasm] (Danio rerio)

Ghost homologue of DDX21 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of DDX21 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of DDX21 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of DDX21 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of DDX21 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of DDX21 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_004719.2, NP_001243839.1

OpenTargets

ENSG00000165732

HPA

ENSG00000165732-DDX21

GeneCards

Q9NR30

Ensembl

ENST00000620315, ENST00000690316, ENSP00000510035, ENST00000354185, ENSG00000165732, ENSP00000346120, ENSP00000480334

PRO

Q9NR30

Pharos - Targets

Q9NR30

HMDB Protein

HMDBP11665

PDB

6L5L, 6L5N, 2M3D, 6L5M, 6L5O

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.874	12
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.669	5
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.623	3
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.589	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.556	3
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.556	3
UniProt:Q99732 LITAF			0.556	3
UniProt:Q8N187 CARTF			0.556	3
UniProt:Q15554 TERF2	2	TERF2 [nucleoplasm] (R-HSA-174895) p-S365-TERF2 [nucleoplasm] (R-HSA-9686530)	0.508	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.482	2
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.462	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:Q9Y2X3 NOP58	3	polySUMO2-K467,K497-NOP58 [nucleoplasm] (R-HSA-4570460) monoSUMO1-K467,K497-NOP58 [nucleoplasm] (R-HSA-4570470) NOP58 [nucleoplasm] (R-HSA-4570488)	0.462	2

Cite Us!