botF HC:LC binds SV2A or B or C and GT1b on the target cell surface

Stable Identifier
R-HSA-5250880
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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botF HC:LC binds SV2A or B or C and GT1b on the target cell surface
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The botulinum toxin type F disulfide-bonded heavy chain - light chain heterodimer ("dichain") (botF HC:LC, encoded by the C. botulinum botF gene) binds ganglioside GT1b and synaptic vesicle protein 2A (SV2A), B (SV2B), or C (SV2C) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SV2A, B, or C when those proteins are exposed at the cell surface by exocytosis (Fu et al. 2009; Rummel et al. 2009).
Literature References
PubMed ID Title Journal Year
19650874 Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

Rummel, A, Häfner, K, Mahrhold, S, Darashchonak, N, Holt, M, Jahn, R, Beermann, S, Karnath, T, Bigalke, H, Binz, T

J. Neurochem. 2009
19476346 Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F

Fu, Z, Chen, C, Barbieri, JT, Kim, JJ, Baldwin, MR

Biochemistry 2009
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Cross References
Mondo
Authored
Krupa, S  (2006-06-15)
Gopinathrao, G  (2006-06-15)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-31)
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