Reactome: A Curated Pathway Database

B-WICH complex positively regulates rRNA expression

Stable Identifier
R-HSA-5250924
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c) (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001, Sarshad et al. 2013, Shen et al. 2013, reviewed in Percipalle and Farrants 2006, , SF3B1, DEK, MYBBP1A, and DDX21. B-WICH is found at active rRNA genes as well as at 5S rRNA and 7SL RNA genes. B-WICH appears to remodel chromatin and recruit histone acetyltransferases that modify histones to transcriptionally active states.

Literature References
Participants
Participant Of
Orthologous Events