B-WICH complex positively regulates rRNA expression

Stable Identifier
R-HSA-5250924
Type
Pathway
Species
Homo sapiens
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The B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c), SF3B1, DEK, MYBBP1A, and DDX21 (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001, Sarshad et al. 2013, Shen et al. 2013, reviewed in Percipalle and Farrants 2006). B-WICH is found at active rRNA genes as well as at 5S rRNA and 7SL RNA genes. B-WICH appears to remodel chromatin and recruit histone acetyltransferases that modify histones to transcriptionally active states.

Literature References
PubMed ID Title Journal Year
16514417 The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription

Percipalle, P, Fomproix, N, Cavellán, E, Voit, R, Reimer, G, Krüger, T, Thyberg, J, Scheer, U, Grummt, I, Farrants, AK

EMBO Rep. 2006
16603771 The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription

Cavellán, E, Asp, P, Percipalle, P, Farrants, AK

J. Biol. Chem. 2006
21559432 The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes

Vintermist, A, Böhm, S, Sadeghifar, F, Louvet, E, Mansén, A, Percipalle, P, Ostlund Farrants, AK

PLoS ONE 2011
16574391 Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1

Percipalle, P, Farrants, AK

Curr. Opin. Cell Biol. 2006
23667505 The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation

Shen, M, Zhou, T, Xie, W, Ling, T, Zhu, Q, Zong, L, Lyu, G, Gao, Q, Zhang, F, Tao, W

PLoS ONE 2013
23555303 Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression

Sarshad, A, Sadeghifar, F, Louvet, E, Mori, R, Böhm, S, Al-Muzzaini, B, Vintermist, A, Fomproix, N, Östlund, AK, Percipalle, P

PLoS Genet. 2013
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