B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9

Stable Identifier
R-HSA-5250938
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Histone acetyltransferases recruited by the B‑WICH complex acetylate histone H3 at lysine‑9. Knockdown of the BAZ1B (WSTF) and MYOIC components of B‑WICH cause a loss of histone acetyltransferases KAT2B (PCAF), KAT2A (GCN5), and EP300 (p300) and a reduction of acetylated histone H3. Knockdown of KAT2B (PCAF) causes a reduction in acetylation of histone H3 at lysine‑9, leading to reduced rRNA synthesis levels (Sarshad et al. 2013, Shen et al. 2013).

Literature References
PubMed ID Title Journal Year
23555303 Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression

Sarshad, A, Sadeghifar, F, Louvet, E, Mori, R, Böhm, S, Al-Muzzaini, B, Vintermist, A, Fomproix, N, Östlund, AK, Percipalle, P

PLoS Genet. 2013
23667505 The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation

Shen, M, Zhou, T, Xie, W, Ling, T, Zhu, Q, Zong, L, Lyu, G, Gao, Q, Zhang, F, Tao, W

PLoS ONE 2013
Participants
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Catalyst Activity
Catalyst Activity
Title
histone acetyltransferase activity of B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm]
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Activity
Orthologous Events
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Created