Toxicity of botulinum toxin type C (BoNT/C)

Stable Identifier
R-HSA-5250971
Type
Pathway
Species
Homo sapiens
Related Species
Clostridium botulinum
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Botulinum toxin type C (BoNT/C) is only very rarely associated with human disease (Hatheway 1995) and a pathway by which it might enter the circulation from the human gut has not been described. Nevertheless, the toxin itself, a disulfide-bonded heavy chain (HC) - light chain (LC) heterodimer (“dichain”), is capable of binding to neurons by interactions with cell surface gangliosides (Karalewitz et al. 2012), the bound toxin can enter synaptic vesicles and release its LC moiety into the cytosol of targeted cells (Montal 2010), and the BoNT/C LC can cleave synaptosomal associated protein 25 (SNAP25) and syntaxin 1 (STX1) on the cytosolic face of the neuronal plasma membrane (Foran et al. 1996). These four events are annotated here.

Literature References
PubMed ID Title Journal Year
8611567 Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release

Foran, P, Lawrence, GW, Shone, CC, Foster, KA, Dolly, JO

Biochemistry 1996
23027864 Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry

Karalewitz, AP, Fu, Z, Baldwin, MR, Kim, JJ, Barbieri, JT

J. Biol. Chem. 2012
20233039 Botulinum neurotoxin: a marvel of protein design

Montal, M

Annu. Rev. Biochem. 2010
8542759 Botulism: the present status of the disease

Hatheway, CL

Curr. Top. Microbiol. Immunol. 1995
Participants
Participant Of
Disease
Name Identifier Synonyms
botulism 11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
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