Toxicity of botulinum toxin type F (BoNT/F)

Stable Identifier
R-HSA-5250981
Type
Pathway
Species
Homo sapiens
Related Species
Clostridium botulinum
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Botulinum toxin type F (BoNT/F) is only very rarely associated with human disease (Hatheway 1995) and a pathway by which it might enter the circulation from the human gut has not been described. Nevertheless, the toxin itself, a disulfide-bonded heavy chain (HC) - light chain (LC) heterodimer ("dichain"), is capable of binding to neurons by interactions with cell-surface ganglioside and synaptic vesicle protein 2 (SV2) (Fu et al. 2009; Rummel et al. 2009), the bound toxin can enter synaptic vesicles and release its LC moiety into the cytosol of targeted cells (Montal 2010), and the BoNT/F LC can cleave vesicle-associated membrane proteins 1 and 2 (VAMP1 and 2) on the cytosolic face of the synaptic vesicle membrane (Yamasaki et al. 1994). These four events are annotated here.

Literature References
PubMed ID Title Journal Year
19650874 Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

Rummel, A, Häfner, K, Mahrhold, S, Darashchonak, N, Holt, M, Jahn, R, Beermann, S, Karnath, T, Bigalke, H, Binz, T

J. Neurochem. 2009
20233039 Botulinum neurotoxin: a marvel of protein design

Montal, M

Annu. Rev. Biochem. 2010
8542759 Botulism: the present status of the disease

Hatheway, CL

Curr. Top. Microbiol. Immunol. 1995
19476346 Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F

Fu, Z, Chen, C, Barbieri, JT, Kim, JJ, Baldwin, MR

Biochemistry 2009
8175689 Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin

Yamasaki, S, Baumeister, A, Binz, T, Blasi, J, Link, E, Cornille, F, Roques, B, Fykse, EM, Südhof, TC, Jahn, R

J Biol Chem 1994
Participants
Participant Of
Disease
Name Identifier Synonyms
botulism 11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Authored
Reviewed
Created