APC R1450* [cytosol]

Stable Identifier
R-HSA-5251499
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
APC R1450* [cytosol] icon
APC R1450* [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
1338904 Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

Miyoshi, Y, Nagase, H, Ando, H, Horii, A, Ichii, S, Nakatsuru, S, Aoki, T, Miki, Y, Mori, T, Nakamura, Y

Hum. Mol. Genet. 1992
11746989 Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability

Shimizu, Y, Ikeda, S, Fujimori, M, Kodama, S, Nakahara, M, Okajima, M, Asahara, T

Genes Chromosomes Cancer 2002
External Reference Information
External Reference
UniProt:P25054 APC
Gene Names
APC, DP2.5
Chain
initiator methionine:1, chain:2-2843
Reference Genes
BioGPS Gene:324 APC
COSMIC (genes):APC APC
CTD Gene:324 APC
dbSNP Gene:324 APC
ENSEMBL:ENSG00000134982 APC
HGNC:583 APC
KEGG Gene (Homo sapiens):324 APC
Monarch:324 APC
NCBI Gene:324 APC
OMIM:611731 APC
UCSC:P25054 APC
Reference Transcript
Other Identifiers
0004920746
11731561_a_at
11731562_s_at
11757692_s_at
13349
16988021
1912_s_at
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
203525_s_at
203526_s_at
203527_s_at
216933_3p_x_at
216933_x_at
2824218
2824220
2824225
2824230
2824232
2824233
2824239
2824244
2824245
2824248
2824253
2824256
2824257
2824258
2824266
2824267
2824268
2824272
2824273
2824274
2824275
2824276
2824277
2824279
2RQU
324
36182_at
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
4YJE
4YJL
4YK6
5B6G
5IZ6
5IZ8
5IZ9
5IZA
8107330
A0A087WYF3
A0A2Q2SV78
A_14_P106747
A_14_P116796
A_14_P135872
A_23_P70213
A_33_P3408983
AAA03586
AAA60353
AAA60354
AAB21145
AC008575
AC136500
AK294544
APC
APC-201
APC-207
BAH11802
CCDS4107
CH471086
D6RFL6
E7EMH9
E9PFT7
EAW49002
EAW49007
ENSG00000134982
ENSP00000257430
ENSP00000427089
ENST00000257430
ENST00000257430.8
ENST00000508376
ENST00000508376.6
EntrezGene:324
EntrezGene:APC
g182396_3p_a_at
g4557318_3p_a_at
GE58061
GO:0000278
GO:0000281
GO:0000776
GO:0001708
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005874
GO:0005881
GO:0005886
GO:0005912
GO:0005913
GO:0005923
GO:0006464
GO:0006950
GO:0006974
GO:0007010
GO:0007026
GO:0007049
GO:0007050
GO:0007059
GO:0007094
GO:0007155
GO:0007165
GO:0007267
GO:0007389
GO:0008013
GO:0008017
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0008286
GO:0009056
GO:0010942
GO:0016020
GO:0016055
GO:0016328
GO:0016342
GO:0016477
GO:0016579
GO:0019887
GO:0019899
GO:0019901
GO:0022607
GO:0030027
GO:0030054
GO:0030154
GO:0030178
GO:0030234
GO:0030335
GO:0030877
GO:0031274
GO:0031625
GO:0032587
GO:0032886
GO:0032991
GO:0034330
GO:0040011
GO:0042592
GO:0042802
GO:0042995
GO:0043065
GO:0043226
GO:0045295
GO:0045595
GO:0045732
GO:0045736
GO:0048471
GO:0048856
GO:0048870
GO:0051010
GO:0051260
GO:0051276
GO:0051301
GO:0051988
GO:0065003
GO:0070830
GO:0070840
GO:0090090
GO:0120162
GO:0140014
GO:1904781
GO:1904885
GO:1904886
GO:1990909
HGNC:583
HPA013349
Hs.75081.0.S2_3p_a_at
Hs.75081.1.S1_3p_a_at
ILMN_1662668
IPR000225
IPR009223
IPR009224
IPR009232
IPR009234
IPR009240
IPR011989
IPR016024
IPR026818
IPR026831
IPR026836
IPR032038
IPR036149
IPR041257
LRG_130
M73548
M73548_at
M74088
M74088_s_at
MIM:114500
MIM:114550
MIM:135290
MIM:175100
MIM:611731
MIM:613659
NM_000038
NM_001127510
NM_001354895
NM_001354896
NM_001354898
NM_001354899
NM_001354900
NM_001354901
NM_001354903
NM_001354904
NM_001354905
NM_001354906
NP_000029
NP_001120982
NP_001341824
NP_001341825
NP_001341827
NP_001341828
NP_001341829
NP_001341830
NP_001341832
NP_001341833
NP_001341834
NP_001341835
PF00514
PF05923
PF05924
PF05937
PF05956
PF05972
PF11414
PF16629
PF16630
PF16633
PF16634
PF16635
PF16636
PF16689
PF18797
PH_hs_0031313
R4GMU6
S78214
SM00185
TC05003398.hg
UPI000013CF60
Participant Of
hasCandidate
Other forms of this molecule
APC G1309Dfs*4 [cytosol]
APC F1197* [cytosol]
APC Q1338* [cytosol]
APC S811* [cytosol]
APC I1417 fs*2 [cytosol]
APC E1554* [cytosol]
APC [nucleoplasm]
p-ub-APC [cytosol]
K63polyUb-APC [cytosol]
APC(1-777) [cytosol]
APC(778-2843) [cytosol]
APC [cytosol]
Modified Residues
Name
L-arginine 1450 replaced with unknown
Coordinate
1450
PsiMod
L-arginine removal [MOD:01632]
A protein modification that effectively removes or replaces an L-arginine.
Disease
Name Identifier Synonyms
colorectal cancer 9256
Cross References
RefSeq
COSMIC
OpenTargets
GeneCards
PRO
Orphanet
PDB
Interactors (22)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P35222 CTNNB1  24 0.955 19
 UniProt:Q15691 MAPRE1  1 0.775 5
 UniProt:P49841 GSK3B  4 0.773 5
 UniProt:P49674 CSNK1E  2 0.75 8
 UniProt:O15169 AXIN1  11 0.725 15
 UniProt:Q5JTC6 AMER1  3 0.723 4
 UniProt:Q14160 SCRIB  1 0.697 5
 UniProt:P60953 CDC42  3 0.684 9
 UniProt:P35221 CTNNA1  2 0.678 3
 UniProt:P14923 JUP  5 0.678 3
 UniProt:Q96N96 SPT13      0.667 5
 UniProt:Q07666 KHDRBS1  3 0.667 4
 UniProt:Q9NR80-3 ARHGEF4      0.646 5
 UniProt:Q8N944 AMER3      0.631 8
 UniProt:Q02248 Ctnnb1  12 0.623 8
 UniProt:O14640 DVL1  4 0.623 6
 UniProt:Q96N96-1 SPATA13      0.619 5
 UniProt:O14641 DVL2  5 0.564 2
 UniProt:Q9NSA3 CTNNBIP1  1 0.564 2
 UniProt:Q14114 LRP8  2 0.558 2
 UniProt:Q13363 CTBP1  3 0.527 2
 IntAct:EBI-6876712 CTNB1      0.499 6