Reactome | AXIN1 P255S [cytosol]

AXIN1 P255S [cytosol]

Stable Identifier

R-HSA-5251505

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by WNT in cancer (Homo sapiens)
    - Signaling by AXIN mutants (Homo sapiens)
      - AXIN missense mutants destabilize the destruction complex (Homo sapiens)
        
        AXIN mutants destabilize the destruction complex (Homo sapiens)
        
        truncation and missense AXIN mutants [cytosol] (Homo sapiens)
        
        AXIN1 P255S [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
12555076	AXIN1 mutations but not deletions in cerebellar medulloblastomas Kleihues, P, Ohgaki, H, Baeza, N, Masuoka, J	Oncogene	2003
11585731	Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas Tonn, JC, Wiestler, OD, Koch, A, Sörensen, N, Dahmen, RP, Berthold, F, Behrens, J, Birchmeier, W, Pietsch, T, Denkhaus, D	Cancer Res.	2001

External Reference Information

External Reference

UniProt:O15169 AXIN1

Gene Names

AXIN1, AXIN

Chain

chain:1-862

Reference Genes

BioGPS Gene:8312 AXIN1

COSMIC (genes):AXIN1 AXIN1

CTD Gene:8312 AXIN1

dbSNP Gene:8312 AXIN1

ENSEMBL:ENSG00000103126 AXIN1

ENSEMBL:ENSG00000103126.15 AXIN1

HGNC:903 AXIN1

KEGG Gene (Homo sapiens):8312 AXIN1

Monarch:8312 AXIN1

NCBI Gene:8312 AXIN1

OMIM:603816 AXIN1

UCSC:O15169 AXIN1

Reference Transcript

Other Identifiers

11754511_a_at

16822408

212849_PM_at

212849_at

33319_at

3675048

3675049

3675051

3675053

3675055

3675056

3675057

3675058

3675059

3675062

3675066

3675069

3675070

3675090

3675091

3675092

7998211

8312

AF009674_at

GE61790

GO:0000209

GO:0001701

GO:0001932

GO:0001934

GO:0002039

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005938

GO:0006325

GO:0006351

GO:0006355

GO:0006913

GO:0006915

GO:0007010

GO:0007605

GO:0008013

GO:0009950

GO:0009953

GO:0010629

GO:0010800

GO:0012501

GO:0015630

GO:0016020

GO:0016055

GO:0016328

GO:0019899

GO:0019901

GO:0019904

GO:0023052

GO:0030154

GO:0030159

GO:0030163

GO:0030178

GO:0030511

GO:0030877

GO:0031122

GO:0031398

GO:0031410

GO:0031625

GO:0032147

GO:0032436

GO:0032991

GO:0033138

GO:0034244

GO:0035591

GO:0036211

GO:0036342

GO:0042802

GO:0042803

GO:0043161

GO:0043226

GO:0043507

GO:0043621

GO:0045599

GO:0045732

GO:0045860

GO:0045893

GO:0046330

GO:0046332

GO:0048318

GO:0048320

GO:0048468

GO:0048471

GO:0048856

GO:0050877

GO:0051248

GO:0051443

GO:0060070

GO:0060090

GO:0060322

GO:0060828

GO:0065003

GO:0070016

GO:0070411

GO:0070412

GO:0071514

GO:0071944

GO:0090090

GO:1990909

GO:2000060

HMNXSV003035039

HMNXSV003043314

Hs.184434.0.S1_3p_at

ILMN_1692967

ILMN_1766185

PH_hs_0026858

TC16000725.hg

Participates

as a candidate of

truncation and missense AXIN mutants [cytosol] (Homo sapiens)

Other forms of this molecule

AXIN1 L396M [cytosol]

AXIN1 Y346* [cytosol]

AXIN1 E406* [cytosol]

AXIN1 W247* [cytosol]

AXIN1 P354L [cytosol]

ub-AXIN1 [cytosol]

Ub-RibC-AXIN1 [cytosol]

AXIN1 [cytosol]

p-T481,S486,S493-AXIN1 [cytosol]

RibC-AXIN1 [cytosol]

Modified Residues

Name

L-proline 255 replaced with L-serine

Coordinate

255

PsiMod

L-proline removal [MOD:01645]

A protein modification that effectively removes or replaces an L-proline.

L-serine residue [MOD:00025]

A protein modification that effectively converts a source amino acid residue to L-serine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
medulloblastoma	DOID:0050902

Cross References

RefSeq

NP_003493.1, NP_851393.1

OpenTargets

ENSG00000103126

HPA

ENSG00000103126-AXIN1

GeneCards

O15169

Ensembl

ENST00000262320, ENSG00000103126, ENSP00000262320, ENSP00000346935, ENST00000354866

PRO

O15169

Pharos - Targets

O15169

Orphanet

24358

HMDB Protein

HMDBP14519

PDB

6JCK, 4NU1, 5WZZ, 1O9U, 1DK8, 4B7T, 4NM3, 1EMU, 4NM7, 3ZDI, 4NM0, 4NM5

Interactors (64)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.975	51
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.94	44
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.845	17
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.782	5
UniProt:Q5JTC6 AMER1	5	AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.708	7
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.687	5
UniProt:P49840 GSK3A	3	GSK3A [cytosol] (R-HSA-198326) p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.669	3
UniProt:P14923 JUP	6	JUP [cytosol] (R-HSA-201598) JUP [cornified envelope] (R-HSA-8847739) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [plasma membrane] (R-HSA-437260)	0.666	4
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.643	4
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.643	4
UniProt:Q9H7D7 WDR26			0.641	4
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.623	10
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.59	3
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.558	4
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q9BQ66 KR412			0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q96KG9-4 SCYL1			0.556	3
UniProt:O94972 TRIM37	1	TRIM37 [cytosol] (R-HSA-976049)	0.556	3
UniProt:Q9C019 TRI15			0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q969G2 LHX4	1	LHX4 [nucleoplasm] (R-HSA-9010585)	0.556	3
UniProt:O15105 SMAD7	2	SMAD7 [nucleoplasm] (R-HSA-178197) SMAD7 [cytosol] (R-HSA-173478)	0.556	8
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
IntAct:EBI-16436498 CCSB ORF ID			0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
IntAct:EBI-16434222 CCSB ORF ID			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:Q96K21-3 ZFYVE19			0.556	3
UniProt:Q2TAC2-2 CCDC57			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
IntAct:EBI-16437007 CCSB ORF ID			0.556	3
IntAct:EBI-16429620 CCSB ORF ID			0.556	3
UniProt:Q15654 TRIP6			0.556	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9HCK0 ZBT26			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:O75581 LRP6	8	p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) LRP6 [early endosome membrane] (R-HSA-5368481) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6N [extracellular region] (R-HSA-5334021) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) LRP6 [plasma membrane] (R-HSA-206252)	0.527	9
UniProt:Q93008 USP9X	1	USP9X [cytosol] (R-HSA-870499)	0.527	2
IntAct:EBI-11789122 GSK3A			0.525	2
UniProt:G1T8E2 G1T8E2			0.525	2
UniProt:Q92837 FRAT1	1	FRAT1 [cytosol] (R-HSA-1226051)	0.525	3
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	4
UniProt:Q5VWQ8-2 DAB2IP			0.524	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	4
UniProt:P23258 TUBG1	1	TUBG1 [cytosol] (R-HSA-379269)	0.512	4
UniProt:Q14194 CRMP1	4	p-Y-CRMP1 [cytosol] (R-HSA-399784) CRMP1 [cytosol] (R-HSA-398120) p-T509,T514,S518,S522-CRMP1 [cytosol] (R-HSA-399777) p-S522-CRMP1 [cytosol] (R-HSA-399779)	0.508	2
UniProt:P39687 ANP32A	1	ANP32A [nucleoplasm] (R-HSA-450467)	0.508	2
UniProt:P49407 ARRB1	5	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	2
UniProt:P46937 YAP1	7	p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.499	11
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.499	4
UniProt:Q60953-2 PML			0.499	2
UniProt:P35813 PPM1A	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.499	2
UniProt:Q99ML9 Rnf111	3	RNF111 [cytosol] (R-MMU-975981) Rnf111 [nucleoplasm] (R-MMU-2186735) RNF111 [nucleoplasm] (R-MMU-2186765)	0.463	5
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.463	2

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