Deletions in the AXIN1 gene prevent expression of AXIN1 protein

Stable Identifier
R-HSA-5251562
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Deletions in the AXIN1 gene prevent expression of AXIN1 protein
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The SNU475 and Alexander hepatocellular carcinoma cells lines carries genomic deletions in the AXIN1 gene, and AXIN1 transcript is not detectable by RT-PCR in the SNU475 line. Both SNU475 and Alexander cells show enhanced nuclear localization of beta-catenin compared to WT cells and increased transcriptional activity as assessed by a TCF-dependent reporter gene, indicating aberrant activation of WNT signaling in the absence of functional AXIN1 protein (Satoh et al, 2000).
Literature References
PubMed ID Title Journal Year
10700176 AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Miwa, N, Tokino, T, Furukawa, Y, Fujita, M, Daigo, Y, Nishiwaki, T, Nakamura, Y, Kato, T, Satoh, S, Kawasoe, T, Yamaoka, Y, Murata, M, Sasaki, Y, Ishiguro, H, Shimano, T, Imaoka, S

Nat. Genet. 2000
Participants
Input
Participates
as an event of
Normal reaction
Expression of AXIN1 gene (Homo sapiens)
Functional status

Decreased transcript level of defective AXIN1 gene [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
hepatocellular carcinoma DOID:684 adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
Authored
Rothfels, K  (2014-01-23)
Reviewed
Salahshor, S  (2014-05-12)
Woodgett, J  (2014-05-22)
Created
Rothfels, K  (2014-02-04)
Cite Us!