HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm

Stable Identifier
R-HSA-5251955
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. It is only able to bind HSP70s when they are bound to ATP. DnaJ homolog subfamily members (aka heat-shock 40 proteins, HSP40s) also translocate to the nucleus under heat-shock stress (Hattori et al. 1992) and can act as stimulators of intrinsic ATPase activity of HSP70s. The result is that Hikeshi dissociates from HSP70:ADP.

Literature References
PubMed ID Title Journal Year
1586970 Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells

Hattori, H, Liu, YC, Tohnai, I, Ueda, M, Kaneda, T, Kobayashi, T, Tanabe, K, Ohtsuka, K

Cell Struct. Funct. 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATPase activator activity of DNAJB1,B6,C2,C7 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created