ATP13A4,5 transport divalent ions from extracellular region to cytosol

Stable Identifier
R-HSA-5251989
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Probable cation-transporting ATPases 13A4 and 13A5 (ATP13A4, 5) belong to the P5 subfamily of P-tpre ATPases. This subfamily is the most poorly understood in terms of chracterisation and function. The yeast orthologue YPK9 (aka Yor291w) shows toxicity when deleted from yeast cells, suggesting a role in sequestration of divalent heavy metal ions (Schmidt et al. 2009). The ATP13A4 gene may be disrupted by a 3q25-q29 inversion of the long arm of chromosome 3, which may result in a specific language impairment (SLI) (Kwasnicka-Crawford et al. 2005).

Literature References
PubMed ID Title Journal Year
19345671 Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2

Schmidt, K, Wolfe, DM, Stiller, B, Pearce, DA

Biochem. Biophys. Res. Commun. 2009
15925480 Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay

Kwasnicka-Crawford, DA, Carson, AR, Roberts, W, Summers, AM, Rehnström, K, Järvelä, I, Scherer, SW

Genomics 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cation-transporting ATPase activity of ATP13A4, 5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed