Reactome | HSPA9 [cytosol]

HSPA9 [cytosol]

Stable Identifier

R-HSA-5251993

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HSPA9 (mtHsp70), Stress-70 protein, mitochondrial, GRP75_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P38646 HSPA9

Gene Names

HSPA9, GRP75, HSPA9B, mt-HSP70

Chain

transit peptide:1-46, chain:47-679

Reference Genes

BioGPS Gene:3313 HSPA9

COSMIC (genes):HSPA9 HSPA9

CTD Gene:3313 HSPA9

dbSNP Gene:3313 HSPA9

ENSEMBL:ENSG00000113013 HSP9

HGNC:5244 HSPA9

KEGG Gene (Homo sapiens):3313 HSPA9

Monarch:3313 HSPA9

NCBI Gene:3313 HSPA9

OMIM:600548 HSPA9

UCSC:P38646 HSPA9

Reference Transcript

RefSeq:NM_004134.6 HSPA9

Other Identifiers

0006760403

11742920_a_at

11742921_s_at

11750745_a_at

11752595_a_at

11759417_s_at

17000485

200690_PM_at

200690_at

200691_PM_s_at

200691_s_at

200692_PM_s_at

200692_s_at

241840_PM_at

241840_at

2529286

2529292

2529293

2877509

2877510

2877511

2877512

2877513

2877514

2877515

2877516

2877518

2877519

2877521

2877524

2877531

2877533

2877535

2877537

2877538

2877541

2877543

2877546

2877547

2877550

2877551

3313

41509_at

41510_s_at

75250_s_at

8114455

86392_at

A_24_P77676

A_24_P934295

GO:0000166

GO:0001401

GO:0002376

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005730

GO:0005737

GO:0005739

GO:0005743

GO:0005744

GO:0005759

GO:0005925

GO:0006457

GO:0006611

GO:0006790

GO:0006810

GO:0006886

GO:0006913

GO:0006950

GO:0007005

GO:0007007

GO:0008150

GO:0008219

GO:0015031

GO:0016226

GO:0016887

GO:0019899

GO:0022607

GO:0030154

GO:0030218

GO:0031072

GO:0031625

GO:0032991

GO:0034620

GO:0042026

GO:0042592

GO:0042645

GO:0043066

GO:0043167

GO:0043226

GO:0044183

GO:0045646

GO:0045647

GO:0048856

GO:0051082

GO:0051085

GO:0051787

GO:0061024

GO:0070062

GO:0140275

GO:0140657

GO:1902037

GO:1903707

HMNXSV003015869

Hs.184233.0.A1_3p_at

ILMN_1679209

L11066_at

L15189_s_at

PH_hs_0029370

TC05001832.hg

g12653414_3p_a_at

g4758569_3p_a_at

Participates

as a component of

Other forms of this molecule

HSPA9 [nucleoplasm]

HSPA9 [mitochondrial matrix]

HSPA9(1-679) [mitochondrial intermembrane space]

HSPA9 [mitochondrial inner membrane]

HSPA9(1-679) [cytosol]

Inferred To

Hspa9 [cytosol] (Mus musculus)

Hspa9 [cytosol] (Rattus norvegicus)

HSPA9 [cytosol] (Bos taurus)

HSPA9 [cytosol] (Canis familiaris)

HSPA9 [cytosol] (Plasmodium falciparum)

HSPA9 [cytosol] (Sus scrofa)

hspa9 [cytosol] (Danio rerio)

hspa9 [cytosol] (Xenopus tropicalis)

Hsc70-5 [cytosol] (Drosophila melanogaster)

hsp-6 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004125.3

OpenTargets

ENSG00000113013

GeneCards

P38646

HPA

ENSG00000113013-HSPA9

Ensembl

ENSP00000297185, ENSG00000113013, ENST00000297185

PRO

P38646

Pharos - Targets

P38646

Orphanet

23644

PDB

6P2U, 6PMT, 3N8E, 4KBO, 6NHK

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.811	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.745	5
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.742	15
UniProt:P21912 SDHB	1	SDHB [mitochondrial inner membrane] (R-HSA-70985)	0.662	10
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.637	11
UniProt:P13693 TCTP			0.567	4
UniProt:Q9HAV7 GRPEL1	1	GRPEL1 [mitochondrial inner membrane] (R-HSA-1252062)	0.564	2
UniProt:A4D2J0 A4D2J0			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:P53051 MALX3			0.556	3
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.527	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.527	3
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	11
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q8WX92 NELFB	3	NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [cytosol] (R-HSA-9603526) NELFB [nucleoplasm] (R-HSA-112427)	0.524	2
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.499	4
UniProt:Q99650 OSMR	1	OSMR [plasma membrane] (R-HSA-448654)	0.499	4
UniProt:Q8N0X7 SPART			0.462	2
UniProt:Q00005 2ABB			0.462	2
UniProt:A6NFY7 SDHF1			0.462	2
UniProt:P47985 UQCRFS1	1	UQCRFS1(79-274) [mitochondrial inner membrane] (R-HSA-164278)	0.462	4
UniProt:Q5U5X0 LYRM7			0.462	2

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