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HSPA9 [cytosol]
Stable Identifier
R-HSA-5251993
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HSPA9 (mtHsp70), Stress-70 protein, mitochondrial, GRP75_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
HSP70s:ADP [cytosol] (Homo sapiens)
HSPA9:ADP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)
HSP70s:ADP [cytosol] (Homo sapiens)
HSPA9:ADP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
Hikeshi binds HSP70s:ATP (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
Hikeshi:HSP70s:ATP [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)
Hikeshi:HSP70s:ATP [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P38646 HSPA9
Gene Names
HSPA9, GRP75, HSPA9B, mt-HSP70
Chain
transit peptide:1-46, chain:47-679
Reference Genes
BioGPS Gene:3313 HSPA9
COSMIC (genes):HSPA9 HSPA9
CTD Gene:3313 HSPA9
dbSNP Gene:3313 HSPA9
ENSEMBL:ENSG00000113013 HSP9
HGNC:5244 HSPA9
KEGG Gene (Homo sapiens):3313 HSPA9
Monarch:3313 HSPA9
NCBI Gene:3313 HSPA9
OMIM:600548 HSPA9
UCSC:P38646 HSPA9
Reference Transcript
RefSeq:NM_004134.6 HSPA9
Other Identifiers
0006760403
11742920_a_at
11742921_s_at
11750745_a_at
11752595_a_at
11759417_s_at
17000485
200690_at
200691_s_at
200692_s_at
241840_at
2529286
2529292
2529293
2877509
2877510
2877511
2877512
2877513
2877514
2877515
2877516
2877518
2877519
2877521
2877524
2877531
2877533
2877535
2877537
2877538
2877541
2877543
2877546
2877547
2877550
2877551
3313
3N8E
41509_at
41510_s_at
4KBO
5219
6NHK
75250_s_at
8114455
86392_at
898
A0A384P5G6
A0A3B3ITI4
A_24_P77676
A_24_P934295
AAA67526
AAH00478
AAH24034
ABF50973
ADO22215
AK222758
AK315177
BAD96478
BAG37618
BC000478
BC024034
CAB005219
CCDS4208
CH471062
D6RA73
D6RCD7
D6RDH7
D6RJI2
DQ531046
EAW62129
ENSG00000113013
ENSP00000297185
ENST00000297185
ENST00000649126.1
EntrezGene:3313
EntrezGene:HSPA9
g12653414_3p_a_at
g4758569_3p_a_at
GE57605
GO:0000166
GO:0002376
GO:0003674
GO:0003723
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005925
GO:0006457
GO:0006611
GO:0006790
GO:0006810
GO:0006913
GO:0006950
GO:0006986
GO:0007165
GO:0008150
GO:0008219
GO:0009058
GO:0015031
GO:0016226
GO:0016887
GO:0019899
GO:0022607
GO:0030154
GO:0030218
GO:0031072
GO:0031625
GO:0034605
GO:0034620
GO:0035722
GO:0042026
GO:0042592
GO:0042623
GO:0042645
GO:0043066
GO:0043167
GO:0043226
GO:0044183
GO:0045646
GO:0045647
GO:0048856
GO:0051082
GO:0051085
GO:0051186
GO:0051787
GO:0070062
GO:1902037
GO:1903707
GQ891353
HGNC:5244
HPA000898
Hs.184233.0.A1_3p_at
HSPA9
HSPA9-201
ILMN_1679209
IPR012725
IPR013126
IPR018181
IPR029047
IPR029048
L11066
L11066_at
L15189
L15189_s_at
MIM:182170
MIM:600548
MIM:616854
NM_004134
NP_004125
PF00012
PH_hs_0029370
PR00301
TC05001832.hg
UPI000012BA4E
Participant Of
hasComponent
HSPA9:ADP [cytosol]
HSPA9:ATP [cytosol]
Other forms of this molecule
HSPA9(1-679) [cytosol]
HSPA9 [mitochondrial inner membrane]
HSPA9(1-679) [mitochondrial intermembrane space]
HSPA9 [mitochondrial matrix]
HSPA9 [nucleoplasm]
Inferred To
HSPA9 [cytosol] (Bos taurus)
HSPA9 [cytosol] (Caenorhabditis elegans)
HSPA9 [cytosol] (Danio rerio)
HSPA9 [cytosol] (Dictyostelium discoideum)
HSPA9 [cytosol] (Drosophila melanogaster)
HSPA9 [cytosol] (Mus musculus)
HSPA9 [cytosol] (Plasmodium falciparum)
HSPA9 [cytosol] (Rattus norvegicus)
HSPA9 [cytosol] (Saccharomyces cerevisiae)
HSPA9 [cytosol] (Schizosaccharomyces pombe)
HSPA9 [cytosol] (Sus scrofa)
HSPA9 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_004125.3
OpenTargets
ENSG00000113013
GeneCards
P38646
PRO
P38646
Orphanet
23644
PDB
6NHK
,
3N8E
,
6P2U
,
4KBO
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.811
6
UniProt:Q8IWL3 HSCB
5
HSCB [mitochondrial inner membrane]
(R-HSA-1299447)
HSCB [mitochondrial matrix]
(R-HSA-1299438)
HSCB(1-235) [mitochondrial inner membrane]
(R-HSA-1299443)
HSCB(1-30) [mitochondrial matrix]
(R-HSA-8986120)
HSCB(1-235) [mitochondrial intermembrane space]
(R-HSA-1299456)
0.742
15
UniProt:P21912 SDHB
1
SDHB [mitochondrial inner membrane]
(R-HSA-70985)
0.662
10
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.659
4
UniProt:O15350 TP73
3
TP73 [cytosol]
(R-HSA-8957239)
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.637
11
UniProt:P13693 TCTP
0.567
4
UniProt:Q9HAV7 GRPEL1
1
GRPEL1 [mitochondrial inner membrane]
(R-HSA-1252062)
0.564
2
UniProt:A4D2J0 A4D2J0
0.556
3
UniProt:P38340 NTM1
0.556
3
UniProt:P53051 MALX3
0.556
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q8WX92 NELFB
3
NELFB [cytosol]
(R-HSA-9603526)
NELFB [mitochondrial outer membrane]
(R-HSA-9603553)
NELFB [nucleoplasm]
(R-HSA-112427)
0.524
2
UniProt:Q9H1K1 ISCU
0.499
4
UniProt:Q14643 ITPR1
2
ITPR1 [endoplasmic reticulum membrane]
(R-HSA-3006433)
ITPR1 [platelet dense tubular network membrane]
(R-HSA-3325593)
0.463
2
UniProt:P21796 VDAC1
4
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
0.463
2
UniProt:Q8N0X7 SPART
0.462
2
UniProt:Q00005 2ABB
0.462
2
UniProt:A6NFY7 SDHF1
0.462
2
UniProt:P47985 UQCRFS1
1
UQCRFS1(79-274) [mitochondrial inner membrane]
(R-HSA-164278)
0.462
4
UniProt:Q5U5X0 LYRM7
0.462
2
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