NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm

Stable Identifier
R-HSA-5252041
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. C11orf73-bound HSP70s bind to the nuclear pore complex (NPC) which transports the complex from the cytosol to the nucleoplasm where HSP70s can counteract heat shock-induced damage (Kose et al. 2012). NPC does not transport ADP-bound HSP70s.

Literature References
PubMed ID Title Journal Year
22541429 Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage

Kose, S, Furuta, M, Imamoto, N

Cell 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created