Reactome | PIP [extracellular region]

PIP [extracellular region]

Stable Identifier

R-HSA-5252061

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Prolactin-inducible protein, PIP_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P12273 PIP

Gene Names

PIP, GCDFP15, GPIP4

Chain

signal peptide:1-28, chain:29-146

Reference Genes

BioGPS Gene:5304 PIP

COSMIC (genes):PIP PIP

CTD Gene:5304 PIP

dbSNP Gene:5304 PIP

ENSEMBL:ENSG00000159763 PIP

HGNC:8993 PIP

KEGG:hsa:5304 PIP

Monarch:5304 PIP

NCBI Gene:5304 PIP

OMIM:176720 PIP

UCSC:P12273 PIP

Reference Transcript

RefSeq:NM_002652.3 PIP

Other Identifiers

11719818_at

17052737

206509_PM_at

206509_at

3028936

3028937

3028942

3028945

3028947

3028948

3028949

325_s_at

41094_at

5304

8136839

A_23_P8702

GE60275

GO:0001580

GO:0002682

GO:0003779

GO:0004190

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0006508

GO:0008092

GO:0010628

GO:0019864

GO:0042802

GO:0070062

GO:0070233

HMNXSV003004868

ILMN_2092077

PH_hs_0005588

TC07000927.hg

g4505820_3p_at

Participates

as a component of

AZGP1:PIP [extracellular region] (Homo sapiens)

as an input of

AZGP1 binds PIP (Homo sapiens)

Inferred To

Homologues of PIP [extracellular region] (Bos taurus)

PIP [extracellular region] (Bos taurus)

PIP [extracellular region] (Sus scrofa)

LOC119874625 [extracellular region] (Canis familiaris)

Pip [extracellular region] (Mus musculus)

Pip [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_002643.1

OpenTargets

ENSG00000159763

ENSEMBL

ENSG00000159763, ENST00000291009, ENSP00000291009

GeneCards

PIP

HPA

ENSG00000159763-PIP

PRO

P12273

Pharos - Targets

P12273

PDB

3ES6

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50570-2 DNM2			0.556	3
UniProt:O14656-2 TOR1A			0.556	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.527	2
UniProt:Q96D71 REPS1	1	REPS1 [cytosol] (R-HSA-8862265)	0.527	2
UniProt:Q7Z494 NPHP3	2	MyrG2-NPHP3 [cytosol] (R-HSA-5624091) MyrG2-NPHP3 [cilium] (R-HSA-5618254)	0.527	2
UniProt:O43166 SIPA1L1	1	SPAR [cytosol] (R-HSA-6794278)	0.527	2
UniProt:P57058 HUNK			0.527	2
UniProt:Q15003 NCAPH	3	p-T-NCAPH [cytosol] (R-HSA-2517885) p-S570-NCAPH [cytosol] (R-HSA-2529017) NCAPH [cytosol] (R-HSA-1638139)	0.527	2
UniProt:Q6Y7W6 GGYF2			0.527	2
UniProt:Q13009 TIAM1	2	TIAM1 [cytosol] (R-HSA-195013) p-Y829-TIAM1 [cytosol] (R-HSA-3928461)	0.527	2
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) pY-PTK2 [cytosol] (R-HSA-9632393)	0.527	2
UniProt:O94887 FARP2	1	FARP2 [cytosol] (R-HSA-396935)	0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:Q9NRL3 STRN4			0.527	2
UniProt:Q8IYB1 M21D2			0.527	2
UniProt:Q8IZD2 KMT2E			0.527	2
UniProt:P53814 SMTN			0.527	2
UniProt:Q00653 NFKB2	6	NFKB2(1-454) [nucleoplasm] (R-HSA-177674) NFKB2(1-454) [cytosol] (R-HSA-168144) p-7S-p100 [cytosol] (R-HSA-5607629) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) NFKB2(1-900) [cytosol] (R-HSA-2677931) monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500)	0.527	2
UniProt:Q5U5Q3 MEX3C	1	MEX3C [cytosol] (R-HSA-8851640)	0.527	2
UniProt:Q2TAL8 QRIC1			0.527	2
UniProt:Q5VT06 CE350			0.527	2
UniProt:Q13492 PICALM	3	PICALM [cytosol] (R-HSA-8867593) PICALM [cytoplasmic vesicle membrane] (R-HSA-429812) PICALM [Golgi membrane] (R-HSA-434341)	0.527	2
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.527	2
UniProt:Q13472 TOP3A	2	TOP3A [mitochondrial matrix] (R-HSA-9914882) TOP3A [nucleoplasm] (R-HSA-912452)	0.527	2
UniProt:Q9H9C1 SPE39			0.527	2
UniProt:Q92628 K0232			0.527	2
UniProt:P52594 AGFG1	1	AGFG1 [cytosol] (R-HSA-8863714)	0.527	2
UniProt:Q13033 STRN3			0.527	2
UniProt:Q27J81 INF2			0.527	2
UniProt:Q92802 N42L2			0.527	2
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.527	2
UniProt:Q96DU7 ITPKC	1	ITPKC [cytosol] (R-HSA-2023850)	0.527	2
UniProt:Q86T24 ZBTB33	1	ZBTB33 [nucleoplasm] (R-HSA-5223282)	0.527	2
UniProt:Q5VSL9 STRP1			0.527	2
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.527	2
UniProt:Q8IWR0 Z3H7A			0.527	2
UniProt:P49792 RANBP2	6	RANBP2 [cytosol] (R-HSA-157703) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [nuclear envelope] (R-HSA-2993756) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720)	0.527	2
UniProt:Q9H6R7 WDCP	2	WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol] (R-HSA-9700468) WDCP(1-680)-ALK(1061-1620) fusion [cytosol] (R-HSA-9700460)	0.527	2
UniProt:Q9P2B4 CT2NL			0.527	2
UniProt:Q15021 NCAPD2	3	p-T1339,T1384,T1389-NCAPD2 [cytosol] (R-HSA-2517887) p-S-NCAPD2 [cytosol] (R-HSA-2529011) NCAPD2 [cytosol] (R-HSA-1638140)	0.527	2
UniProt:O75170 PP6R2			0.527	2
UniProt:Q3V6T2 CCDC88A	1	CCDC88A [cytosol] (R-HSA-9715191)	0.527	2
UniProt:A7MCY6 TBKB1			0.527	2
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.527	2

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