ATP6AP1 binds V-ATPase

Stable Identifier
R-HSA-5252133
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Vacuolar-type H+-ATPases (V-ATPases) are proton pumps that acidify intracellular cargos and deliver protons across the plasma membrane of many specialised cells. V-type proton ATPase subunit S1 (ATP6AP1) is thought to function as an accessory subunit of the V0 subcomplex of V-ATPase, facilitating acidification (Supek et al. 1994). Experiments with the mouse orthologue reveals a role for Atp6ap1 in osteoclast formation and function (Qin et al. 2011).

Literature References
PubMed ID Title Journal Year
7929063 A novel accessory subunit for vacuolar H(+)-ATPase from chromaffin granules

Supek, F, Supekova, L, Mandiyan, S, Pan, YC, Nelson, H, Nelson, N

J. Biol. Chem. 1994
22087256 Versatile roles of V-ATPases accessory subunit Ac45 in osteoclast formation and function

Qin, A, Cheng, TS, Lin, Z, Pavlos, NJ, Jiang, Q, Xu, J, Dai, KR, Zheng, MH

PLoS ONE 2011
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