Reactome | BAG2 [cytosol]

BAG2 [cytosol]

Stable Identifier

R-HSA-5255445

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BAG family molecular chaperone regulator 2, BAG2_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - Regulation of HSF1-mediated heat shock response (Homo sapiens)
      - HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
        
        HSP70 NEFs [cytosol] (Homo sapiens)
        
        BAG1-5 [cytosol] (Homo sapiens)
        
        BAG2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95816 BAG2

Gene Names

BAG2

Chain

initiator methionine:1, chain:2-211

Reference Genes

BioGPS Gene:9532 BAG2

COSMIC (genes):BAG2 BAG2

CTD Gene:9532 BAG2

dbSNP Gene:9532 BAG2

ENSEMBL:ENSG00000112208 BAG2

HGNC:938 BAG2

KEGG Gene (Homo sapiens):9532 BAG2

Monarch:9532 BAG2

NCBI Gene:9532 BAG2

OMIM:603882 BAG2

UCSC:O95816 BAG2

Reference Transcript

Other Identifiers

0000430739

11742904_s_at

11748602_a_at

17009853

209406_at

230750_at

2911373

2911374

2911382

2911384

2911385

2911386

2911390

2911392

2911394

2911396

2911397

2911398

2911399

2911400

2911402

35291_at

8120402

9532

A_14_P124996

A_23_P356554

GE55675

GO:0000774

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0006457

GO:0006464

GO:0006950

GO:0008092

GO:0008150

GO:0009056

GO:0010954

GO:0019538

GO:0019899

GO:0030234

GO:0030424

GO:0030425

GO:0031072

GO:0031397

GO:0031625

GO:0032091

GO:0032991

GO:0042802

GO:0043226

GO:0044325

GO:0048156

GO:0050821

GO:0051087

GO:0051604

GO:0101031

GO:1900034

GO:1901588

GO:1901800

GO:1904667

Hs.94769.2.A1_3p_at

ILMN_1759618

ILMN_3244893

TC06000684.hg

g4322819_3p_s_at

Participant Of

hasMember

BAG1-5 [cytosol]

Inferred To

CG17014 [cytosol] (Drosophila melanogaster)

Bag2 [cytosol] (Mus musculus)

Bag2 [cytosol] (Rattus norvegicus)

BAG2 [cytosol] (Bos taurus)

BAG2 [cytosol] (Canis familiaris)

BAG2 [cytosol] (Sus scrofa)

bag2 [cytosol] (Danio rerio)

bag2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_005249547.1, XP_011513301.1, XP_011513300.1, NP_004273.1

OpenTargets

ENSG00000112208

HPA

ENSG00000112208-BAG2

GeneCards

O95816

Ensembl

ENSP00000359727, ENST00000370693, ENSG00000112208

PRO

O95816

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	10	HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.779	8
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.623	3
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.564	3
UniProt:Q99558 MAP3K14	5	MAP3K14 [cytosol] (R-HSA-168189) Active NIK [cytosol] (R-HSA-5607646) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.499	4
UniProt:Q13164 MAPK7	4	MAPK7 [cytosol] (R-HSA-198754) MAPK7 [nucleoplasm] (R-HSA-199961) p-T218,Y220-MAPK7 [cytosol] (R-HSA-198721) p-T218,Y220-MAPK7 [nucleoplasm] (R-HSA-198738)	0.499	3

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