Reactome | BAG2 [cytosol]

BAG2 [cytosol]

Stable Identifier

R-HSA-5255445

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BAG family molecular chaperone regulator 2, BAG2_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - Regulation of HSF1-mediated heat shock response (Homo sapiens)
      - HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
        
        HSP70 NEFs [cytosol] (Homo sapiens)
        
        BAG1-5 [cytosol] (Homo sapiens)
        
        BAG2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95816 BAG2

Gene Names

BAG2

Chain

initiator methionine:, chain:2-211

Reference Genes

BioGPS Gene:9532 BAG2

COSMIC (genes):BAG2 BAG2

CTD Gene:9532 BAG2

dbSNP Gene:9532 BAG2

ENSEMBL:ENSG00000112208 BAG2

ENSEMBL_homo_sapiens_GENE:ENSG00000112208.11 BAG2

HGNC:938 BAG2

KEGG Gene (Homo sapiens):9532 BAG2

Monarch:9532 BAG2

NCBI Gene:9532 BAG2

OMIM:603882 BAG2

UCSC:O95816 BAG2

Reference Transcript

Other Identifiers

11742904_s_at

11748602_a_at

17009853

209406_PM_at

209406_at

230750_PM_at

230750_at

2911373

2911374

2911382

2911384

2911385

2911386

2911390

2911392

2911394

2911396

2911397

2911398

2911399

2911400

2911402

35291_at

8120402

9532

A_14_P124996

A_23_P356554

GE55675

GO:0000774

GO:0005515

GO:0005829

GO:0005856

GO:0005874

GO:0006457

GO:0008092

GO:0010954

GO:0019538

GO:0030163

GO:0030424

GO:0030425

GO:0031072

GO:0031397

GO:0031625

GO:0032091

GO:0036211

GO:0042802

GO:0043226

GO:0044325

GO:0048156

GO:0050821

GO:0051087

GO:0051604

GO:0098772

GO:0101031

GO:1901588

GO:1901800

GO:1904667

HMNXSV003024752

Hs.94769.2.A1_3p_at

TC06000684.hg

g4322819_3p_s_at

Participates

as a member of

BAG1-5 [cytosol] (Homo sapiens)

Inferred To

unc-23 [cytosol] (Caenorhabditis elegans)

Bag2 [cytosol] (Mus musculus)

Bag2 [cytosol] (Rattus norvegicus)

BAG2 [cytosol] (Bos taurus)

BAG2 [cytosol] (Canis familiaris)

BAG2 [cytosol] (Sus scrofa)

bag2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011513301.1, XP_005249547.1, XP_011513300.1, NP_004273.1

OpenTargets

ENSG00000112208

GeneCards

O95816

HPA

ENSG00000112208-BAG2

Ensembl

ENSP00000359727, ENST00000370693, ENSG00000112208

PRO

O95816

Pharos - Targets

O95816

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.823	10
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.669	12
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.643	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.623	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.623	5
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.564	3
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.527	3
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.527	2
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.527	2
UniProt:P25685 DNAJB1	3	p-S149,S151,S171 DNAJB1 [cytosol] (R-HSA-5690241) DNAJB1 [cytosol] (R-HSA-3299666) DNAJB1 [nucleoplasm] (R-HSA-5082366)	0.527	2
UniProt:Q13164 MAPK7	4	MAPK7 [nucleoplasm] (R-HSA-199961) MAPK7 [cytosol] (R-HSA-198754) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738)	0.499	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	11
UniProt:O75161 NPHP4	1	NPHP4 [cytosol] (R-HSA-2059925)	0.483	2

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