Reactome | BAG2 [cytosol]

BAG2 [cytosol]

Stable Identifier

R-HSA-5255445

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BAG family molecular chaperone regulator 2, BAG2_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - Regulation of HSF1-mediated heat shock response (Homo sapiens)
      - HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
        
        HSP70 NEFs [cytosol] (Homo sapiens)
        
        BAG1-5 [cytosol] (Homo sapiens)
        
        BAG2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95816 BAG2

Gene Names

BAG2

Chain

initiator methionine:1, chain:2-211

Reference Genes

BioGPS Gene:9532 BAG2

COSMIC (genes):BAG2 BAG2

CTD Gene:9532 BAG2

dbSNP Gene:9532 BAG2

ENSEMBL:ENSG00000112208 BAG2

HGNC:938 BAG2

KEGG:hsa:9532 BAG2

Monarch:9532 BAG2

NCBI Gene:9532 BAG2

OMIM:603882 BAG2

UCSC:O95816 BAG2

Reference Transcript

Other Identifiers

11742904_s_at

11748602_a_at

17009853

209406_PM_at

209406_at

230750_PM_at

230750_at

2911373

2911374

2911382

2911384

2911385

2911386

2911390

2911392

2911394

2911396

2911397

2911398

2911399

2911400

2911402

35291_at

8120402

9532

A_14_P124996

A_23_P356554

GE55675

GO:0000774

GO:0005515

GO:0005829

GO:0005874

GO:0006457

GO:0008092

GO:0010954

GO:0019538

GO:0030424

GO:0030425

GO:0031072

GO:0031397

GO:0031625

GO:0042802

GO:0044325

GO:0045862

GO:0048156

GO:0050821

GO:0051087

GO:0098772

GO:0101031

GO:1901588

GO:1901800

HMNXSV003024752

Hs.94769.2.A1_3p_at

TC06000684.hg

g4322819_3p_s_at

Participates

as a member of

BAG1-5 [cytosol] (Homo sapiens)

This entity regulates

Positively

Nascent polyprotein starts folding in ER (Homo sapiens)

Inferred To

unc-23 [cytosol] (Caenorhabditis elegans)

CG17014 [cytosol] (Drosophila melanogaster)

Bag2 [cytosol] (Mus musculus)

Bag2 [cytosol] (Rattus norvegicus)

BAG2 [cytosol] (Bos taurus)

BAG2 [cytosol] (Canis familiaris)

BAG2 [cytosol] (Sus scrofa)

bag2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011513300.1, XP_011513301.1, XP_054212829.1, XP_005249547.1, XP_054212830.1, NP_004273.1

OpenTargets

ENSG00000112208

ENSEMBL

ENST00000370693, ENSP00000359727, ENSG00000112208

GeneCards

BAG2

HPA

ENSG00000112208-BAG2

PRO

O95816

Pharos - Targets

O95816

GlyGen

O95816

Interactors (63)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.865	11
UniProt:Q99615 DNAJC7	2	DNAJC7 [nucleoplasm] (R-HSA-5255408) DNAJC7 [cytosol] (R-HSA-5252099)	0.802	5
UniProt:Q15773 MLF2			0.723	6
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.708	6
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.681	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.669	12
UniProt:Q03933 HSF2			0.669	3
UniProt:P54253 ATX1			0.666	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.643	4
UniProt:Q71U36 TUBA1A	9	TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A unfolded [cytosol] (R-HSA-392767) TUBA1A folding intermediate [cytosol] (R-HSA-392805) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312)	0.643	5
UniProt:Q15833 STXBP2	2	STXBP2 [extracellular region] (R-HSA-8862990) STXBP2 [cytosol] (R-HSA-5617151)	0.643	4
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.623	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.623	3
UniProt:Q8AZK7 EBNA5			0.623	3
UniProt:O75161 NPHP4	1	NPHP4 [cytosol] (R-HSA-2059925)	0.615	4
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.59	3
UniProt:P23258 TUBG1	1	TUBG1 [cytosol] (R-HSA-379269)	0.569	3
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:P58340 MLF1			0.564	2
UniProt:O95072 REC8	1	REC8 [nucleoplasm] (R-HSA-163028)	0.564	2
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.564	2
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:Q5T1M5 FKB15			0.527	3
UniProt:Q9UDY4 DNJB4			0.527	2
UniProt:Q7Z5L9 I2BP2			0.527	3
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.527	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	3
UniProt:P46937 YAP1	8	YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.527	2
UniProt:P04150 NR3C1	3	NR3C1 [nucleoplasm] (R-HSA-879837) NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106)	0.527	2
UniProt:Q3B7T1 EDRF1			0.527	3
UniProt:Q8IYB5 SMAP1			0.527	2
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.527	2
UniProt:Q9Y217 MTMR6	1	MTMR6 [cytosol] (R-HSA-1604666)	0.527	2
UniProt:Q5T6F2 UBAP2			0.527	2
UniProt:O75190 DNAJB6	2	DNAJB6 [nucleoplasm] (R-HSA-5255425) DNAJB6 [cytosol] (R-HSA-5252014)	0.527	2
UniProt:Q9H1B7 I2BPL			0.527	3
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.527	2
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.527	3
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.527	3
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.527	2
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.527	2
UniProt:O14628 ZNF195	1	ZNF195 [nucleoplasm] (R-HSA-975029)	0.527	2
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.527	2
UniProt:O60885 BRD4	1	BRD4 [nucleoplasm] (R-HSA-9680425)	0.527	2
UniProt:P25685 DNAJB1	3	DNAJB1 [nucleoplasm] (R-HSA-5082366) DNAJB1 [cytosol] (R-HSA-3299666) p-S149,S151,S171 DNAJB1 [cytosol] (R-HSA-5690241)	0.527	2
UniProt:Q9H6K1 ILRUN			0.527	2
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.527	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.527	3
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.527	2
UniProt:Q9NVT9 ARMC1			0.527	2
UniProt:O75165 DNAJC13	3	DNAJC13 [azurophil granule membrane] (R-HSA-6799140) DNAJC13 [plasma membrane] (R-HSA-6806255) DNAJC13 [secretory granule membrane] (R-HSA-6800951)	0.527	3
UniProt:Q9H4A3 WNK1	1	WNK1 [cytosol] (R-HSA-2672391)	0.527	2
UniProt:Q14249 NUCG			0.527	3
UniProt:Q9UJF2 RASAL2	1	RASAL2 [cytosol] (R-HSA-5658224)	0.527	2
UniProt:P53367 ARFP1			0.527	2
UniProt:Q86V48 LUZP1			0.527	2
UniProt:Q99614 TTC1			0.527	2
UniProt:Q96BE0 Q96BE0			0.499	2
UniProt:Q13164 MAPK7	4	p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) MAPK7 [cytosol] (R-HSA-198754) MAPK7 [nucleoplasm] (R-HSA-199961)	0.499	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	11
UniProt:Q9NXB0 MKS1	1	MKS1 [cytosol] (R-HSA-5610400)	0.483	2
UniProt:Q15468 STIL			0.483	2
UniProt:Q00005 2ABB			0.462	3

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