Reactome | BAG3 [cytosol]

BAG3 [cytosol]

Stable Identifier

R-HSA-5255451

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BAG family molecular chaperone regulator 3, BAG3_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - Regulation of HSF1-mediated heat shock response (Homo sapiens)
      - HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
        
        HSP70 NEFs [cytosol] (Homo sapiens)
        
        BAG1-5 [cytosol] (Homo sapiens)
        
        BAG3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95817 BAG3

Gene Names

BAG3, BIS

Chain

initiator methionine:1, chain:2-575

Reference Genes

BioGPS Gene:9531 BAG3

COSMIC (genes):BAG3 BAG3

CTD Gene:9531 BAG3

dbSNP Gene:9531 BAG3

ENSEMBL:ENSG00000151929 BAG3

HGNC:939 BAG3

KEGG Gene (Homo sapiens):9531 BAG3

Monarch:9531 BAG3

NCBI Gene:9531 BAG3

OMIM:603883 BAG3

UCSC:O95817 BAG3

Reference Transcript

RefSeq:NM_004281.3 BAG3

Other Identifiers

11757360_s_at

16709856

217911_s_at

3267315

3267316

3267317

3267318

3267324

3267325

3267326

3267328

3267331

3267332

3267333

3267334

3267335

3267336

3267337

48971_at

7930921

9531

A_23_P47077

A_23_P52552

GE81375

GO:0000045

GO:0000774

GO:0001725

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006457

GO:0006605

GO:0006810

GO:0006913

GO:0006914

GO:0006915

GO:0006950

GO:0007005

GO:0007165

GO:0007420

GO:0008150

GO:0008219

GO:0008625

GO:0009056

GO:0009058

GO:0010664

GO:0015031

GO:0016235

GO:0021510

GO:0022607

GO:0030018

GO:0030234

GO:0030705

GO:0032991

GO:0034605

GO:0034620

GO:0034641

GO:0042307

GO:0042592

GO:0043005

GO:0043066

GO:0043226

GO:0044877

GO:0045296

GO:0045505

GO:0046716

GO:0046827

GO:0048856

GO:0050790

GO:0050821

GO:0051087

GO:0061684

GO:0070842

GO:0071260

GO:0072321

GO:0097192

GO:0097201

GO:0098840

GO:0101031

GO:1900034

GO:1903215

GO:1905337

ILMN_1659766

PH_hs_0001425

TC10000868.hg

g6631072_3p_s_at

Participant Of

hasMember

BAG1-5 [cytosol]

Inferred To

bag102 [cytosol] (Schizosaccharomyces pombe)

Homologues of BAG3 [cytosol] (Schizosaccharomyces pombe)

bag3 [cytosol] (Danio rerio)

bag3 [cytosol] (Xenopus tropicalis)

BAG3 [cytosol] (Bos taurus)

BAG3 [cytosol] (Canis familiaris)

BAG3 [cytosol] (Sus scrofa)

Bag3 [cytosol] (Mus musculus)

Bag3 [cytosol] (Rattus norvegicus)

bag101 [cytosol] (Schizosaccharomyces pombe)

stv [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_004272.2

OpenTargets

ENSG00000151929

HPA

ENSG00000151929-BAG3

GeneCards

O95817

Ensembl

ENST00000369085, ENSP00000358081, ENSG00000151929

PRO

O95817

Orphanet

18453

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.822	7
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.718	6
UniProt:Q00613 HSF1	11	p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) HSF1 [cytosol] (R-HSA-3371452) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416)	0.638	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.623	3
UniProt:P11142 HSPA8	10	HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.597	4
UniProt:P50570 DNM2	5	DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [cytosol] (R-HSA-2213180) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [lysosomal membrane] (R-HSA-2980840)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P0DMV8 HSPA1A	4	HSPA1A [nucleoplasm] (R-HSA-6792605) HSPA1A [cytosol] (R-HSA-6792602) HSPA1A [extracellular region] (R-HSA-6805872) HSPA1A [ficolin-1-rich granule lumen] (R-HSA-6801496)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [cytosol] (R-HSA-162411) TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) DVL2 [cytosol] (R-HSA-201694) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.553	2
UniProt:Q13501 SQSTM1	2	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961)	0.537	3

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