p-AKT2 phosphorylates C2CD5

Stable Identifier
R-HSA-5260201
Type
Reaction [transition]
Species
Homo sapiens
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The protein kinase B beta (AKT) pathway mediates insulin-stimulated glucose transport by increasing glucose transporter GLUT4 translocation from intracellular stores to the plasma membrane. C2 domain-containing protein 5 (C2CD5 aka C2 domain-containing phosphoprotein 138kDa) has been shown to be required for optimal insulin-stimulated GLUT4 translocation and fusion of GLUT4 vesicles with the plasma membrane in adipocytes. It is also able to bind Ca2+ and lipid membranes in its C2 domain. C2CD5 is a substrate for RAC-beta serine/threonine-protein kinase (AKT2), which phosphorylates C2CD5 at serine 197. Phosphorylated C2CD5 optimises GLUT4 translocation to the plasma membrane. The role of human C2CD5 is inferred from the role of the orthologous mouse protein (Xie et al. 2011).

Literature References
PubMed ID Title Journal Year
21907143 C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane

Xie, X, Gong, Z, Mansuy-Aubert, V, Zhou, QL, Tatulian, SA, Sehrt, D, Gnad, F, Brill, LM, Motamedchaboki, K, Chen, Y, Czech, MP, Mann, M, Kr├╝ger, M, Jiang, ZY

Cell Metab. 2011
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Catalyst Activity
Title
protein serine/threonine kinase activity of p-T309,S474-AKT2 [plasma membrane]
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