Mechanical stress and repetitive muscle contraction often causes membrane disruption to the sarcolemma. Healthy muscle is able to repair these disruptions by a Ca2+-dependent pathway. The combination of dysferlin (DYSF), caveolin 3 (CAV3) and tripartite motif-containing protein 72 TRIM72 aka MG53) appears to be essential for the repair of muscle membrane damage (Cai et al. 2009). CAV3 probably acts as a scaffolding protein in caveolar membranes and can interact with DYSF (Matsuda et al. 2001), a surface membrane protein which promotes the fusion of intracellular vesicles with each other and with the sarcolemma at the site of injury. TRIM72 is required for transport of DYSF to the site of injury.