Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HDAC6 [cytosol]
Stable Identifier
R-HSA-5324660
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HDAC6_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q99836 MYD88
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
HDAC6 deacetylates microtubules (Homo sapiens)
HDAC6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBN7 HDAC6
Gene Names
HDAC6, KIAA0901, JM21
Chain
chain:1-1215
Reference Genes
BioGPS Gene:10013 HDAC6
COSMIC (genes):HDAC6 HDAC6
CTD Gene:10013 HDAC6
dbSNP Gene:10013 HDAC6
ENSEMBL:ENSG00000094631 HDAC6
ENSEMBL_homo_sapiens_GENE:ENSG00000094631.22 HDAC6
HGNC:14064 HDAC6
KEGG Gene (Homo sapiens):10013 HDAC6
Monarch:10013 HDAC6
NCBI Gene:10013 HDAC6
OMIM:300272 HDAC6
UCSC:Q9UBN7 HDAC6
Reference Transcript
RefSeq:NM_001321226.1 HDAC6
RefSeq:NM_001321228.1 HDAC6
RefSeq:NM_006044.3 HDAC6
RefSeq:NM_001321227.1 HDAC6
RefSeq:NM_001321229.1 HDAC6
Other Identifiers
10013
11725083_s_at
11748402_a_at
11750582_a_at
11751547_a_at
11754957_a_at
11756962_x_at
17103451
206846_PM_s_at
206846_s_at
216224_PM_s_at
216224_s_at
35795_at
3976849
3976850
3976851
3976852
3976853
3976854
3976855
3976856
3976857
3976858
3976859
3976860
3976861
3976862
3976863
3976864
3976866
3976868
3976870
3976871
3976875
3976876
3976879
3976881
3976883
3976884
3976885
3976886
3976887
3976888
3976889
3976891
3976893
3976894
3976895
3976896
3976899
3976900
3976901
3976902
3976903
3976904
3976905
3976907
3976908
3976909
3976910
8167369
A_23_P250455
A_33_P3320619
GE56783
GO:0000118
GO:0000122
GO:0000209
GO:0000978
GO:0001222
GO:0001932
GO:0001975
GO:0002376
GO:0003677
GO:0003779
GO:0003824
GO:0004407
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005771
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005874
GO:0005875
GO:0005886
GO:0005901
GO:0005929
GO:0006325
GO:0006351
GO:0006355
GO:0006476
GO:0006511
GO:0006515
GO:0006886
GO:0006914
GO:0007005
GO:0007010
GO:0007015
GO:0007018
GO:0007026
GO:0008013
GO:0008017
GO:0008092
GO:0008270
GO:0010506
GO:0010558
GO:0010634
GO:0010727
GO:0010821
GO:0010977
GO:0015630
GO:0016234
GO:0016235
GO:0016241
GO:0016575
GO:0016787
GO:0019213
GO:0019896
GO:0019899
GO:0023052
GO:0030154
GO:0030163
GO:0030182
GO:0030424
GO:0030425
GO:0031252
GO:0031333
GO:0031410
GO:0031593
GO:0031625
GO:0031647
GO:0031648
GO:0032418
GO:0032984
GO:0032991
GO:0033138
GO:0033558
GO:0034330
GO:0034605
GO:0034983
GO:0035902
GO:0035967
GO:0036064
GO:0036211
GO:0042826
GO:0042903
GO:0042995
GO:0043005
GO:0043014
GO:0043025
GO:0043130
GO:0043131
GO:0043162
GO:0043204
GO:0043226
GO:0043242
GO:0044782
GO:0045598
GO:0045814
GO:0045861
GO:0045892
GO:0046872
GO:0048156
GO:0048471
GO:0048487
GO:0048668
GO:0048843
GO:0048856
GO:0048870
GO:0050775
GO:0051354
GO:0051412
GO:0051646
GO:0051787
GO:0051788
GO:0051879
GO:0051968
GO:0060271
GO:0060632
GO:0060765
GO:0060997
GO:0061523
GO:0061734
GO:0065003
GO:0070201
GO:0070301
GO:0070507
GO:0070840
GO:0070842
GO:0070845
GO:0070848
GO:0071218
GO:0071374
GO:0071548
GO:0090042
GO:0090044
GO:0098779
GO:0140096
GO:1900409
GO:1901984
GO:1903146
GO:1904056
GO:1904115
GO:2000273
HMNXSV003006402
Hs.6764.2.S1_3p_a_at
ILMN_1798546
PH_hs_0000680
TC0X000261.hg
g13128863_3p_a_at
Participates
as a component of
HDAC6:VCP:protein aggregates [cytosol] (Homo sapiens)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Homo sapiens)
VCP:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
Other forms of this molecule
HDAC6 [nucleoplasm]
HDAC6 [late endosome lumen]
HDAC6 [lysosomal lumen]
Inferred To
clr3 [cytosol]
(Schizosaccharomyces pombe)
hda-10 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of HDAC6 [cytosol]
(Gallus gallus)
Ghost homologue of HDAC6 [cytosol]
(Rattus norvegicus)
Ghost homologue of HDAC6 [cytosol]
(Xenopus tropicalis)
hdaD [cytosol]
(Dictyostelium discoideum)
HDAC6 [cytosol]
(Bos taurus)
HDAC6 [cytosol]
(Canis familiaris)
HDAC6 [cytosol]
(Danio rerio)
HDAC6 [cytosol]
(Drosophila melanogaster)
HDAC6 [cytosol]
(Mus musculus)
HDAC6 [cytosol]
(Plasmodium falciparum)
HDAC6 [cytosol]
(Sus scrofa)
HDA1 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001308157.1
,
NP_001308155.1
,
NP_001308158.1
,
NP_006035.2
,
NP_001308156.1
ZINC - World Drugs
HDAC6_HUMAN
Guide to Pharmacology - Targets
2618
OpenTargets
ENSG00000094631
ZINC - FDA approved
HDAC6_HUMAN
ZINC - Substances
HDAC6_HUMAN
ZINC - Biogenic
HDAC6_HUMAN
ZINC target
Q9UBN7
PRO
Q9UBN7
PDB
5KH3
,
7ZYU
,
6CE8
,
3GV4
,
8G45
,
8G44
,
6CED
,
5EDU
,
5WBN
,
6CEC
,
6CE6
,
8G43
,
5KH9
,
5B8D
,
6CEA
,
3C5K
,
5WPB
,
3PHD
,
6CEF
,
5KH7
,
6CEE
ZINC - Investigational
HDAC6_HUMAN
GeneCards
Q9UBN7
HPA
ENSG00000094631-HDAC6
Ensembl
ENSP00000402751
,
ENSP00000496013
,
ENSG00000094631
,
ENSP00000496046
,
ENSP00000365831
,
ENSP00000365795
,
ENST00000376619
,
ENST00000643374
,
ENSP00000334061
,
ENST00000423941
,
ENST00000644068
,
ENSP00000392815
,
ENST00000376643
,
ENST00000334136
,
ENSP00000365804
,
ENST00000440653
,
ENST00000443563
,
ENST00000376610
,
ENSP00000394377
Pharos - Targets
Q9UBN7
Orphanet
19581
ZINC - Predictions - Purchasable
HDAC6_HUMAN
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.809
12
UniProt:Q14247 CTTN
2
CTTN [cytosol]
(R-HSA-201894)
p-S113-CTTN [cytosol]
(R-HSA-442842)
0.721
5
UniProt:Q9Y263 PLAP
0.643
3
UniProt:P04610 TAT
0.631
11
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.602
6
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.602
4
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.593
3
UniProt:Q9NQC7 CYLD
3
K48polyUb-K338, K530-CYLD [cytosol]
(R-HSA-9818664)
p-S418-CYLD [cytosol]
(R-HSA-5212667)
CYLD [cytosol]
(R-HSA-741420)
0.576
4
UniProt:O43490 PROM1
0.567
4
UniProt:P21146
4
phospho-p-S29-ADRBK1 [cytosol]
(R-BTA-9645318)
ADRBK1 [cilium]
(R-BTA-5632504)
phospho-p-S29-ADRBK1 [plasma membrane]
(R-BTA-111969)
GRK2 [plasma membrane]
(R-BTA-50270)
0.558
3
UniProt:Q60598 Cttn
2
p-S113-Cttn [cytosol]
(R-MMU-442839)
Cttn [cytosol]
(R-MMU-442836)
0.556
3
UniProt:Q14203-5 DCTN1
0.556
6
UniProt:Q13148 TADBP
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.553
2
UniProt:P21860 ERBB3
0.553
2
UniProt:Q15303 ERBB4
0.553
2
UniProt:Q71U36 TUBA1A
9
AcK-TUBA1A [cytosol]
(R-HSA-5618312)
Ac K40 TUBA1A [axonemal microtubule]
(R-HSA-5624852)
TUBA1A folding intermediate [cytosol]
(R-HSA-392805)
TUBA1A unfolded [cytosol]
(R-HSA-392767)
L-isoglutamyl polyglycyl-TUBA1A [cytosol]
(R-HSA-8867428)
Polyglutamyl-TUBA1A [cytosol]
(R-HSA-8867408)
TUBA1A(1-450) [cytosol]
(R-HSA-8955577)
TUBA1A [cytosol]
(R-HSA-191689)
TUBA1A [axonemal microtubule]
(R-HSA-5610433)
0.534
2
UniProt:O00295 TULP2
0.527
3
UniProt:P31689 DNAJA1
2
SOH-C149,C150-DNAJA1 [cytosol]
(R-HSA-9857072)
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
2
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.527
3
UniProt:Q96S82 UBL7
0.527
2
UniProt:Q9BQK8 LPIN3
3
p-S106-LPIN3 [nucleoplasm]
(R-HSA-4419935)
LPIN3 [nuclear envelope]
(R-HSA-4419928)
LPIN3 [endoplasmic reticulum membrane]
(R-HSA-549160)
0.527
2
UniProt:O43448 KCNAB3
1
KCNAB3 [plasma membrane]
(R-HSA-1297367)
0.527
2
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.527
2
UniProt:P11182 DBT
11
DBT [cytosol]
(R-HSA-9714663)
I98M Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865057)
Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-70017)
Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859151)
Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859144)
2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859145)
LipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859167)
DBT [mitochondrial matrix]
(R-HSA-6792584)
P276C Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865046)
S399C Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865036)
K313_Y338del Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865051)
0.527
2
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.524
6
UniProt:Q9HCU9 BRMS1
1
BRMS1 [nucleoplasm]
(R-HSA-4650034)
0.524
2
UniProt:Q62623
3
Cdc20 [nucleoplasm]
(R-RNO-6783069)
Cdc20 [nucleoplasm]
(R-RNO-174112)
Cdc20 [cytosol]
(R-RNO-141412)
0.524
2
UniProt:Q9NQ11 ATP13A2
1
ATP13A2 [lysosomal lumen]
(R-HSA-939762)
0.508
2
UniProt:Q9H9Y6 POLR1B
1
POLR1B [nucleoplasm]
(R-HSA-63496)
0.488
2
UniProt:P03409 TAX
0.463
4
UniProt:Q8IXJ6 SIRT2
1
SIRT2 [cytosol]
(R-HSA-2161118)
0.463
2
UniProt:P25098 GRK2
4
p-S29-ADRBK1 [cytosol]
(R-HSA-9645318)
ADRBK1 [cilium]
(R-HSA-5632504)
p-S29-ADRBK1 [plasma membrane]
(R-HSA-111969)
GRK2 [plasma membrane]
(R-HSA-50270)
0.463
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text