Nephrin mediated activation of N-WASP

Stable Identifier
R-HSA-532603
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The NCK adaptor protein binds to a proline rich region on WASP and N-WASP through its SH3 domains and has been implicated in the recruitment of WASP/N-WASP to sites of tyrosine phosphorylation. NCK stimulates actin nucleation by N WASP:Arp2/3 complexes. Recruitment of NCK to phosphorylated YDxV sites on nephrin could therefore directly control the cytoskeletal actin architecture of podocytes.

Participants
Participant Of
Orthologous Events