Nephrin mediated activation of N-WASP

Stable Identifier
R-HSA-532603
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The NCK adaptor protein binds to a proline rich region on WASP and N-WASP through its SH3 domains and has been implicated in the recruitment of WASP/N-WASP to sites of tyrosine phosphorylation. NCK stimulates actin nucleation by N WASP:Arp2/3 complexes. Recruitment of NCK to phosphorylated YDxV sites on nephrin could therefore directly control the cytoskeletal actin architecture of podocytes.

Literature References
PubMed ID Title Journal Year
16525419 Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

Jones, N, Blasutig, IM, Eremina, V, Ruston, JM, Bladt, F, Li, H, Huang, H, Larose, L, Li, SS, Takano, T, Quaggin, SE, Pawson, T

Nature 2006
11340081 Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

Rohatgi, R, Nollau, P, Ho, HY, Kirschner, MW, Mayer, BJ

J Biol Chem 2001
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