Reactome | Nephrin mediated activation of N-WASP

Nephrin mediated activation of N-WASP

Stable Identifier

R-HSA-532603

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The NCK adaptor protein binds to a proline rich region on WASP and N-WASP through its SH3 domains and has been implicated in the recruitment of WASP/N-WASP to sites of tyrosine phosphorylation. NCK stimulates actin nucleation by N WASP:Arp2/3 complexes. Recruitment of NCK to phosphorylated YDxV sites on nephrin could therefore directly control the cytoskeletal actin architecture of podocytes.

Literature References

PubMed ID	Title	Journal	Year
11340081	Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway Rohatgi, R, Nollau, P, Ho, HY, Kirschner, MW, Mayer, BJ	J Biol Chem	2001
16525419	Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes Jones, N, Blasutig, IM, Eremina, V, Ruston, JM, Bladt, F, Li, H, Huang, H, Larose, L, Li, SS, Takano, T, Quaggin, SE, Pawson, T	Nature	2006