Reactome | GANAB [endoplasmic reticulum lumen]

GANAB [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-532674

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Neutral alpha-glucosidase AB, GANAB_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q14697 GANAB

Gene Names

GANAB, G2AN, KIAA0088

Chain

signal peptide:1-28, chain:29-944

Reference Genes

BioGPS Gene:23193 GANAB

COSMIC (genes):GANAB GANAB

CTD Gene:23193 GANAB

dbSNP Gene:23193 GANAB

ENSEMBL:ENSG00000089597 GANAB

ENSEMBL_homo_sapiens_GENE:ENSG00000089597.18 GANAB

HGNC:4138 GANAB

KEGG Gene (Homo sapiens):23193 GANAB

Monarch:23193 GANAB

NCBI Gene:23193 GANAB

OMIM:104160 GANAB

UCSC:Q14697 GANAB

Reference Transcript

Other Identifiers

11738988_a_at

11738989_a_at

11738990_x_at

11748926_a_at

11755270_a_at

16739396

211934_PM_x_at

211934_x_at

214626_PM_s_at

214626_s_at

23193

2650289

3137952

3375949

3375950

3375952

3375953

3375954

3375955

3375956

3375957

3375958

3375960

3375961

3375962

3375963

3375964

3375965

3375966

3375967

3375968

3375970

3375971

3375973

3375974

3375975

3375976

3375978

3375979

3375982

3375983

3375984

3375985

3375988

3375989

37040_at

58894_f_at

7948744

88835_at

A_23_P203406

A_23_P399851

D42041_at

GE57201

GE81944

GO:0003723

GO:0003824

GO:0004553

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005794

GO:0005975

GO:0006491

GO:0008152

GO:0016020

GO:0016787

GO:0016798

GO:0017177

GO:0030246

GO:0031410

GO:0033919

GO:0042470

GO:0043226

GO:0043231

GO:0070062

GO:0090599

GO:1901135

HMNXSV003029392

Hs.76847.0.A2_3p_a_at

Hs.76847.1.A2_3p_a_at

ILMN_1739441

PH_hs_0027692

TC11001873.hg

Participates

as a component of

glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)

Cross References

RefSeq

NP_001265121.1, NP_001265122.1, NP_938149.2, NP_001265123.1, NP_938148.1

ZINC - World Drugs

GANAB_HUMAN

OpenTargets

ENSG00000089597

ZINC - Substances

GANAB_HUMAN

ZINC - Biogenic

GANAB_HUMAN

ZINC target

Q14697

PRO

Q14697

PDB

8EMR, 8D43

ZINC - Investigational

GANAB_HUMAN

ZINC - Metabolites

GANAB_HUMAN

GeneCards

Q14697

HPA

ENSG00000089597-GANAB

Ensembl

ENST00000346178, ENSP00000340466, ENSG00000089597, ENST00000356638, ENST00000534613, ENST00000532402, ENST00000526210, ENSP00000432181, ENSP00000433799, ENSP00000434921, ENSP00000349053

Pharos - Targets

Q14697

ZINC - Predictions - Purchasable

GANAB_HUMAN

Orphanet

23911

HMDB Protein

HMDBP00366

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	17
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	4