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GANAB [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-532674
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Neutral alpha-glucosidase AB, GANAB_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
ER-alpha glucosidases bind ER-alpha glucosidase inhibitors (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
N-glycan trimming of Spike (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
ER-alpha glucosidases bind ER-alpha glucosidase inhibitors (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
N-glycan glucose trimming of Spike (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
Calnexin/calreticulin cycle (Homo sapiens)
Removal of the third glucose by glucosidase II and release from the chaperone (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
Removal of the second glucose by glucosidase II (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
GANAB [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14697 GANAB
Gene Names
GANAB, G2AN, KIAA0088
Chain
signal peptide:1-28, chain:29-944
Reference Genes
BioGPS Gene:23193 GANAB
COSMIC (genes):GANAB GANAB
CTD Gene:23193 GANAB
dbSNP Gene:23193 GANAB
ENSEMBL:ENSG00000089597 GANAB
HGNC:4138 GANAB
KEGG:hsa:23193 GANAB
Monarch:23193 GANAB
NCBI Gene:23193 GANAB
OMIM:104160 GANAB
UCSC:Q14697 GANAB
Reference Transcript
RefSeq:NM_001278194.1 GANAB
RefSeq:NM_198335.3 GANAB
RefSeq:NM_198334.2 GANAB
RefSeq:NM_001278192.1 GANAB
RefSeq:NM_001278193.1 GANAB
Other Identifiers
11738988_a_at
11738989_a_at
11738990_x_at
11748926_a_at
11755270_a_at
16739396
211934_PM_x_at
211934_x_at
214626_PM_s_at
214626_s_at
23193
2650289
3137952
3375949
3375950
3375952
3375953
3375954
3375955
3375956
3375957
3375958
3375959
3375960
3375961
3375962
3375963
3375964
3375965
3375966
3375967
3375968
3375970
3375971
3375972
3375973
3375974
3375975
3375976
3375977
3375978
3375979
3375982
3375983
3375984
3375985
3375988
3375989
3375991
3375992
37040_at
53968_PM_at
53968_at
58894_f_at
7948744
88835_at
A_23_P203406
A_23_P399851
D42041_at
GE57201
GE81944
GO:0003723
GO:0003824
GO:0004553
GO:0005515
GO:0005783
GO:0005788
GO:0005794
GO:0005975
GO:0006491
GO:0016020
GO:0016787
GO:0016798
GO:0017177
GO:0030246
GO:0031410
GO:0033919
GO:0042470
GO:0043226
GO:0043231
GO:0070062
GO:0090599
GO:1901135
HMNXSV003019789
HMNXSV003029392
Hs.6259.0.S1_3p_s_at
Hs.76847.0.A2_3p_a_at
Hs.76847.1.A2_3p_a_at
ILMN_1739441
PH_hs_0027692
TC11001873.hg
Participates
as a component of
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
Cross References
RefSeq
NP_001265123.1
,
NP_938149.2
,
NP_001265121.1
,
NP_001265122.1
,
NP_938148.1
ZINC - World Drugs
GANAB_HUMAN
OpenTargets
ENSG00000089597
ENSEMBL
ENSP00000433799
,
ENST00000534613
,
ENSP00000349053
,
ENST00000532402
,
ENST00000346178
,
ENSP00000340466
,
ENSP00000434921
,
ENST00000356638
,
ENSP00000432181
,
ENST00000526210
ZINC - Substances
GANAB_HUMAN
ZINC - Biogenic
GANAB_HUMAN
ZINC target
Q14697
PRO
Q14697
GlyGen
Q14697
PDB
8D43
,
8EMR
ZINC - Investigational
GANAB_HUMAN
ZINC - Metabolites
GANAB_HUMAN
HPA
ENSG00000089597-GANAB
Pharos - Targets
Q14697
Orphanet
GANAB
ZINC - Predictions - Purchasable
GANAB_HUMAN
HMDB Protein
HMDBP00366
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
17
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.527
2
UniProt:P04578 env
7
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
0.462
4
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