RPA1 binds HSF1

Stable Identifier
R-HSA-5333051
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Replication protein A (RPA) is a heterotrimeric, single-strand DNA-binding protein required for DNA metabolism, including DNA replication, repair, and recombination. The physical interaction between the wing motif of human HSF1 and RPA1 was found to provide HSF1 access to nucleosomal DNA, which is important for both basal and inducible gene expression. This access lead to preloading of RNA polymerase II and opened the chromatin structure by recruiting a histone chaperone FACT (Fujimoto M et al. 2012).

Literature References
PubMed ID Title Journal Year
22940245 RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT

Fujimoto, M, Takaki, E, Takii, R, Tan, K, Prakasam, R, Hayashida, N, Iemura, S, Natsume, T, Nakai, A

Mol. Cell 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created