TFC7L2 mutants don't bind CTBP

Stable Identifier
R-HSA-5334052
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TCF7L2 is subject to frameshift and missense mutations in gastric and colorectal cancers that abolish the CTBP binding domain (Duval et al, 1999a; Duval et al, 1999b; Duval et al, 2000; Tang et al, 2008). These mutant proteins fail to colocalize with CTBP and are unable to repress TCF-mediated transcription in vitro (Cuilliere-Dartigues et al, 2006).

Literature References
PubMed ID Title Journal Year
16547505 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription

Cuilliere-Dartigues, P, El-Bchiri, J, Krimi, A, Buhard, O, Fontanges, P, Fléjou, JF, Hamelin, R, Duval, A

Oncogene 2006
10919662 The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines

Duval, A, Rolland, S, Tubacher, E, Bui, H, Thomas, G, Hamelin, R

Cancer Res. 2000
10485457 Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability

Duval, A, Gayet, J, Zhou, XP, Iacopetta, B, Thomas, G, Hamelin, R

Cancer Res. 1999
18621708 A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

Tang, W, Dodge, M, Gundapaneni, D, Michnoff, C, Roth, M, Lum, L

Proc. Natl. Acad. Sci. U.S.A. 2008
10597289 Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability

Duval, A, Iacopetta, B, Ranzani, GN, Lothe, RA, Thomas, G, Hamelin, R

Oncogene 1999
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
colorectal cancer 9256
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