The C-terminal region of DNMT3L associates with C-terminal regions of DNMT3B-isoform1 and DNMT3B-isoform2 (Chen et al. 2005, Van Emburgh and Robertson 2011, human DNMT3L with mouse Dnmt3b in Suetake et al. 2004). DNMT3L binds the unmethylated N-terminus of histone H3 (Ooi et al. 2007), leading DNMT3L to target DNMT3B to chromatin (Wienholz et al. 2010). As inferred from mouse homologs, DNMT3B also binds the unmodified N-terminus of histone H3.