Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
HBEGF(20-208) [endocytic vesicle membrane]
Stable Identifier
R-HSA-5334776
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endocytic vesicle membrane
Synonyms
HBEGF, pro-HBEGF, Proheparin-binding EGF-like growth factor
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of diphtheria toxin (Homo sapiens)
DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)
DT:HBEGF:CD9 [endocytic vesicle membrane] (Homo sapiens)
HBEGF(20-208) [endocytic vesicle membrane] (Homo sapiens)
HBEGF(20-208) [endocytic vesicle membrane] (Homo sapiens)
DT:HBEGF:CD9 is transported from clathrin-coated vesicle to endosome (Homo sapiens)
DT:HBEGF:CD9 [endocytic vesicle membrane] (Homo sapiens)
HBEGF(20-208) [endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99075 HBEGF
Gene Names
HBEGF, DTR, DTS, HEGFL
Chain
signal peptide:1-19, chain:20-208, propeptide:20-62, chain:63-148, propeptide:149-208
Reference Genes
BioGPS Gene:1839 HBEGF
COSMIC (genes):HBEGF HBEGF
CTD Gene:1839 HBEGF
dbSNP Gene:1839 HBEGF
ENSEMBL:ENSG00000113070 HBEGF
HGNC:3059 HBEGF
KEGG Gene (Homo sapiens):1839 HBEGF
Monarch:1839 HBEGF
NCBI Gene:1839 HBEGF
OMIM:126150 HBEGF
UCSC:Q99075 HBEGF
Reference Transcript
RefSeq:NM_001945.2 HBEGF
Other Identifiers
0005700288
11719898_s_at
11755981_a_at
17000724
1839
203821_at
2878274
2878275
2878276
2878278
2878281
2878283
2878284
2878285
2878286
38037_at
8114572
A_23_P213944
A_24_P140608
GE81091
GO:0000165
GO:0003013
GO:0003674
GO:0005154
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005886
GO:0005887
GO:0006464
GO:0006950
GO:0007165
GO:0007173
GO:0007517
GO:0008016
GO:0008083
GO:0008150
GO:0008201
GO:0008283
GO:0008284
GO:0009058
GO:0009986
GO:0016020
GO:0016021
GO:0016477
GO:0030307
GO:0030335
GO:0030665
GO:0030666
GO:0030669
GO:0031410
GO:0035313
GO:0038128
GO:0040007
GO:0040011
GO:0042059
GO:0043167
GO:0043226
GO:0045741
GO:0048661
GO:0048856
GO:0048870
GO:0050731
GO:0051545
GO:0051549
GO:0051897
GO:0060326
GO:0061024
GO:0090303
GO:2000145
HMNXSV003003454
ILMN_2121408
M60278_at
PH_hs_0000094
TC05001854.hg
g4503412_3p_s_at
Participates
as an output of
DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)
as a component of
DT:HBEGF:CD9 [endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
HBEGF(63-148) [clathrin-coated endocytic vesicle membrane]
HBEGF(20-208) [clathrin-coated endocytic vesicle membrane]
HBEGF(20-208) [plasma membrane]
HB-EGF(161-208) [plasma membrane]
HBEGF(20-62) [extracellular region]
HBEGF(149-208) [extracellular region]
HBEGF(20-208) [plasma membrane]
HBEGF(63-148) [extracellular region]
Cross References
RefSeq
NP_001936.1
OpenTargets
ENSG00000113070
GeneCards
Q99075
HPA
ENSG00000113070-HBEGF
Ensembl
ENSP00000230990
,
ENST00000230990
,
ENSG00000113070
PRO
Q99075
HMDB Protein
HMDBP02701
PDB
1XDT
,
2M8S
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.609
3
UniProt:P22607 FGFR3
40
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 795fs*139 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
p-6Y-FGFR3 S371C [plasma membrane]
(R-HSA-2011886)
p-6Y-FGFR3 G370C [plasma membrane]
(R-HSA-2011883)
p-6Y-FGFR3 Y373C [plasma membrane]
(R-HSA-2011889)
p-6Y-FGFR3 795fs*139 [plasma membrane]
(R-HSA-2038360)
p-6Y-FGFR3 R248C [plasma membrane]
(R-HSA-2011884)
pY-FGFR3 [plasma membrane]
(R-HSA-2038368)
p-6Y-FGFR3 K650Q [plasma membrane]
(R-HSA-2032962)
p-6Y-FGFR3 K650N [plasma membrane]
(R-HSA-2032961)
p-6Y-FGFR3 K650E [plasma membrane]
(R-HSA-2032952)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853147)
p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853155)
p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853145)
p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853129)
p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853151)
p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853128)
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
0.556
3
UniProt:P06396 GSN
7
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [extracellular region]
(R-HSA-6806510)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text