CUTC binds Cu+

Stable Identifier
R-HSA-5334788
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

A potential regulator of human copper metabolism has recently been described. Copper homeostasis protein cutC homolog (CutC) is a highly conserved cytosolic copper binding protein (Li et al. 2005, Li et al. 2010). Its function in human copper metabolism remains unclear but in C. elegans, the orthologous cutc1 protein down-regulation increases sensitivity to high levels of copper (Calafato et al. 2008).

Literature References
PubMed ID Title Journal Year
19878721 Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site

Li, Y, Du, J, Zhang, P, Ding, J

J. Struct. Biol. 2010
16182249 Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC

Li, J, Ji, C, Chen, J, Yang, Z, Wang, Y, Fei, X, Zheng, M, Gu, X, Wen, G, Xie, Y, Mao, Y

Biochem. Biophys. Res. Commun. 2005
18723824 Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper

Calafato, S, Swain, S, Hughes, S, Kille, P, Stürzenbaum, SR

Toxicol. Sci. 2008
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