Diphtheria toxin fragments A and B, linked by a disulfide bond (DT A:B) (Collier and Kandel 1971; DeLange et al. 1979; Lambotte et al. 1980; Michel et al. 1972) bind to molecules of proheparin-binding EGF-like growth factor (HBEGF) and CD9 antigen on the target cell plasma membrane. While binding to HBEGF is sufficient for DT A:B uptake into a target cell, presence of CD9 on the target cell surface substantially increases its sensitivity to DT and cross-linking and immunopreciptitation studies indicate that DT A:B, HBEGF, and CD9 form a complex on the cell surface (Brown et al. 1993; Iwamoto et al. 1994). The organization and order of assembly of the complex are not known.
Iwamoto, R, Higashiyama, S, Mitamura, T, Taniguchi, N, Klagsbrun, M, Mekada, E
Collier, RJ, Kandel, J
Brown, JG, Almond, BD, Naglich, JG, Eidels, L
Lambotte, P, Falmagne, P, Capiau, C, Zanen, J, Ruysschaert, JM, Dirkx, J
DeLange, RJ, Williams, LC, Drazin, RE, Collier, RJ
Michel, A, Zanen, J, Monier, C, Crispeels, C, Dirkx, J
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