GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol

Stable Identifier
R-HSA-5339524
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Tetrameric GLUT1, the SLC2A1 gene product, associated with the plasma membrane, mediates the facilitated diffusion of glucose (Glc) into cells. GLUT1 is expressed by many cell types, notably endothelial cells, red blood cells and cells of the brain. Its low Km for glucose (~1 mM) relative to normal blood glucose concentration (~5 mM) allows these cells to take up glucose independent of changes in blood glucose levels. It has been purified from red blood cells and biochemically characterized (Hruz & Mueckler 2001, Liu et al. 2001). Cytosolic ATP associates with GLUT1 and inhibits its glucose transporter activity. Fibroblast growth factor 21 (FGF21) is a potent positive regulator of glucose uptake in differentiated mouse 3T3-L1 adipocytes and in primary human adipocytes, probably acting by stimulating SLC2A1 / GLUT1 gene transcription.

Literature References
PubMed ID Title Journal Year
15902306 FGF-21 as a novel metabolic regulator

Kharitonenkov, A, Shiyanova, TL, Koester, A, Ford, AM, Micanovic, R, Galbreath, EJ, Sandusky, GE, Hammond, LJ, Moyers, JS, Owens, RA, Gromada, J, Brozinick, JT, Hawkins, ED, Wroblewski, VJ, Li, DS, Mehrbod, F, Jaskunas, SR, Shanafelt, AB

J. Clin. Invest. 2005
11425315 The predicted ATP-binding domains in the hexose transporter GLUT1 critically affect transporter activity.

Liu, Q, Vera, JC, Peng, H, Golde, DW

Biochemistry 2001
11681785 Structural analysis of the GLUT1 facilitative glucose transporter (review).

Hruz, PW, Mueckler, MM

Mol Membr Biol 2001
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Event Information
Catalyst Activity
Catalyst Activity
Title
D-glucose transmembrane transporter activity of GLUT1 / SLC2A1 tetramer [plasma membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
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