Uptake and actions of bacterial toxins

Stable Identifier
R-HSA-5339562
Type
Pathway
Species
Homo sapiens
Related Species
Clostridium botulinum, Corynephage beta, Bacillus anthracis, Clostridium tetani
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The toxic effects of many bacteria on their human hosts are mediated by proteins released from the bacteria that enter human cells and disrupt critical cellular functions (Henkel et al. 2010). All of the ones annotated here share a bipartiite mechanism of host intoxication: one moiety binds target cells and mediates the delivery of the other part to the intracellular compartment where it can function as an enzyme to degrade or derivatize and inactivate critical target cell proteins or to activate constitutive synthesis of high levels of cAMP.

Literature References
PubMed ID Title Journal Year
20358680 Toxins from bacteria

Henkel, JS, Baldwin, MR, Barbieri, JT

EXS 2010
Participants
Participant Of
Disease
Name Identifier Synonyms
primary bacterial infectious disease 0050338
Created