Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TCF7L2 R397W [nucleoplasm]
Stable Identifier
R-HSA-5339696
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by TCF7L2 mutants (Homo sapiens)
TFC7L2 mutants don't bind CTBP (Homo sapiens)
TCF7L2 mutants [nucleoplasm] (Homo sapiens)
TCF7L2 R397W [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
18621708
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
Dodge, M
,
Lum, L
,
Gundapaneni, D
,
Michnoff, C
,
Tang, W
,
Roth, M
Proc. Natl. Acad. Sci. U.S.A.
2008
External Reference Information
External Reference
UniProt:Q9NQB0 TCF7L2
Gene Names
TCF7L2, TCF4
Chain
chain:1-619
Reference Genes
BioGPS Gene:6934 TCF7L2
COSMIC (genes):TCF4 TCF7L2
COSMIC (genes):TCF7L2 TCF7L2
CTD Gene:6934 TCF7L2
dbSNP Gene:6934 TCF7L2
ENSEMBL:ENSG00000148737 TCF7L2
HGNC:11641 TCF7L2
KEGG:hsa:6934 TCF7L2
Monarch:6934 TCF7L2
NCBI Gene:6934 TCF7L2
OMIM:602228 TCF7L2
UCSC:Q9NQB0 TCF7L2
Reference Transcript
RefSeq:NM_001198531.1 TCF7L2
RefSeq:NM_001198526.1 TCF7L2
RefSeq:NM_001146284.1 TCF7L2
RefSeq:XM_005270103.1 TCF7L2
RefSeq:NM_001146286.1 TCF7L2
RefSeq:NM_001146283.1 TCF7L2
RefSeq:NM_001146274.1 TCF7L2
RefSeq:XM_005270089.1 TCF7L2
RefSeq:XM_005270096.2 TCF7L2
RefSeq:NM_001198528.1 TCF7L2
RefSeq:XM_005270084.1 TCF7L2
RefSeq:XM_017016592.1 TCF7L2
RefSeq:XM_017016593.1 TCF7L2
Participates
as a candidate of
TCF7L2 mutants [nucleoplasm] (Homo sapiens)
Other forms of this molecule
TCF7L2 [nucleoplasm]
pT201,T212-TCF7L2 [nucleoplasm]
TCF7L2 K485fs*25 [nucleoplasm]
Modified Residues
Name
L-arginine 397 replaced with L-tryptophan
Coordinate
397
PsiMod
L-tryptophan residue [MOD:00027]
A protein modification that effectively converts a source amino acid residue to L-tryptophan.
L-arginine removal [MOD:01632]
A protein modification that effectively removes or replaces an L-arginine.
Disease
Name
Identifier
Synonyms
colorectal cancer
DOID:9256
Cross References
RefSeq
NP_001139758.1
,
NP_001139755.1
,
NP_001185457.1
,
NP_001185455.1
,
NP_001185460.1
,
XP_005270146.1
,
XP_016872081.1
,
NP_001139746.1
,
NP_001139756.1
,
XP_005270153.1
,
XP_016872082.1
,
XP_005270141.1
,
XP_005270160.1
OpenTargets
ENSG00000148737
ENSEMBL
ENST00000369397
,
ENSP00000446172
,
ENST00000355717
,
ENST00000538897
,
ENSP00000348274
,
ENSP00000358404
,
ENSP00000486891
,
ENST00000627217
,
ENST00000352065
,
ENSP00000344823
,
ENSG00000148737
,
ENSP00000347949
,
ENST00000355995
HPA
ENSG00000148737-TCF7L2
GeneCards
TCF7L2
PRO
Q9NQB0
Pharos - Targets
Q9NQB0
Orphanet
TCF7L2
PDB
1JDH
,
1JPW
,
2GL7
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.97
27
UniProt:Q13761 RUNX3
7
RUNX3 [nucleoplasm]
(R-HSA-8865393)
RUNX3 [cytosol]
(R-HSA-8937797)
Ac-K94,K171-RUNX3 [nucleoplasm]
(R-HSA-8951965)
PolyUb-K94,K148-RUNX3 [cytosol]
(R-HSA-8952400)
PolyUb-K94,K148-RUNX3 [nucleoplasm]
(R-HSA-8952387)
p-Y-RUNX3 [cytosol]
(R-HSA-8937805)
PolyUb-RUNX3 [nucleoplasm]
(R-HSA-8952417)
0.656
14
UniProt:Q08050 FOXM1
3
p-T611,S730,S739-FOXM1 [nucleoplasm]
(R-HSA-4088133)
p-T611-FOXM1 [nucleoplasm]
(R-HSA-4088026)
FOXM1 [nucleoplasm]
(R-HSA-4088019)
0.612
7
UniProt:Q14526 HIC1
2
monoSUMO1-K333-HIC1 [nucleoplasm]
(R-HSA-4090368)
HIC1 [nucleoplasm]
(R-HSA-4090364)
0.61
6
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.597
6
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.543
5
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text