Signaling by TCF7L2 mutants

Stable Identifier
R-HSA-5339700
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Signaling by TCF7L2 mutants
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~50% of colorectal cancers with microsatellite instability show frameshift mutations in TCF7L2 that result in the loss of the CTBP-binding region (Duval et al, 1999; Cuillliere-Dartigues et al, 2006). These cancer cells show decreased colocalization of CTBP and TCF7L2 and have increased expression of a TCF-dependent reporter gene (Cuilliere-Dartigues et al, 2006).
Literature References
PubMed ID Title Journal Year
16547505 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription

Duval, A, El-Bchiri, J, Cuilliere-Dartigues, P, Hamelin, R, Fontanges, P, Buhard, O, Fléjou, JF, Krimi, A

Oncogene 2006
Participants
Events
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as an event of
Disease
Name Identifier Synonyms
colorectal cancer DOID:9256
Authored
Rothfels, K  (2014-04-03)
Reviewed
Salahshor, S  (2014-05-12)
Woodgett, J  (2014-05-22)
Created
Rothfels, K  (2014-03-08)
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