Misspliced GSK3beta mutants stabilize beta-catenin

Stable Identifier
R-HSA-5339716
Type
Pathway
Species
Homo sapiens
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GSK3beta is subject to in-frame missplicing in CML stem cells resulting in the production of mutant protein that lacks the AXIN and FRAT binding domains. Cells containing this mutant GSK3beta show elevated levels of nuclear beta-catenin and enhanced TCF-dependent reporter activity (Jamieson et al, 2008; Abrahamsson et al, 2009).

Literature References
PubMed ID Title Journal Year
19237556 Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation

Abrahamsson, AE, Geron, I, Gotlib, J, Dao, KH, Barroga, CF, Newton, IG, Giles, FJ, Durocher, J, Creusot, RS, Karimi, M, Jones, C, Zehnder, JL, Keating, A, Negrin, RS, Weissman, IL, Jamieson, CH

Proc. Natl. Acad. Sci. U.S.A. 2009
15306667 Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

Jamieson, CH, Ailles, LE, Dylla, SJ, Muijtjens, M, Jones, C, Zehnder, JL, Gotlib, J, Li, K, Manz, MG, Keating, A, Sawyers, CL, Weissman, IL

N. Engl. J. Med. 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
chronic myeloid leukemia 8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Cross References
BioModels Database
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