HAVCR2 binds LGALS9

Stable Identifier
R-HSA-5340385
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
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Summation

T-helper (Th) cell-mediated immunity is required to eliminate pathogens effectively but unrestrained Th activity can contribute to tissue damage in many inflammatory and autoimmune diseases. The T-cell immunoglobulin and mucin domain-containing protein (HAVCR2, TIM3) inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and allo-immune responses and promotes immunological tolerance when it binds to its ligand, galectin-9 (LGALS9). The HAVCR2:LGALS9 complex achieves this inhibition by inducing apoptosis of Th1 cells. The human event is inferred from experimental data from mouse studies (Sanchez-Fueyo et al. 2003, Zhu et al. 2005).

Literature References
PubMed ID Title Journal Year
16286920 The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

Zhu, C, Anderson, AC, Schubart, A, Xiong, H, Imitola, J, Khoury, SJ, Zheng, XX, Strom, TB, Kuchroo, VK

Nat. Immunol. 2005
14556005 Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance

Sánchez-Fueyo, A, Tian, J, Picarella, D, Domenig, C, Zheng, XX, Sabatos, CA, Manlongat, N, Bender, O, Kamradt, T, Kuchroo, VK, Gutiérrez-Ramos, JC, Coyle, AJ, Strom, TB

Nat. Immunol. 2003
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Havcr2 binds Lgals9 (Mus musculus)
Authored
Jassal, B  (2014-03-17)
Reviewed
D'Eustachio, P  (2015-02-11)