Reactome | DDB2 [nucleoplasm]

DDB2 [nucleoplasm]

Stable Identifier

R-HSA-53491

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DDB2, DNA damage binding protein 2, DNA damage binding protein 2, Damage-specific DNA binding protein 2, DDB p48 subunit, DDBb, UV-damaged DNA-binding protein 2, UV-DDB 2

Locations in the PathwayBrowser for interactor UniProt:Q16531 DDB1

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
        
        TP53 stimulates DDB2 expression (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92466 DDB2

Gene Names

DDB2

Chain

chain:1-427

Reference Genes

BioGPS Gene:1643 DDB2

COSMIC (genes):DDB2 DDB2

CTD Gene:1643 DDB2

dbSNP Gene:1643 DDB2

ENSEMBL:ENSG00000134574 DDB2

ENSEMBL_homo_sapiens_GENE:ENSG00000134574.12 DDB2

HGNC:2718 DDB2

KEGG Gene (Homo sapiens):1643 DDB2

Monarch:1643 DDB2

NCBI Gene:1643 DDB2

OMIM:600811 DDB2

UCSC:Q92466 DDB2

Reference Transcript

Other Identifiers

11717397_a_at

11750080_a_at

1243_at

1643

16724471

203409_PM_at

203409_at

3327739

3329650

3329651

3329655

3329656

3329658

3329663

3329665

3329667

3329668

3329673

3329674

3329677

3329678

3329680

3329681

3329682

3329683

3329684

7939738

A_14_P111520

A_23_P52610

A_33_P3383955

GE58979

GO:0000209

GO:0000785

GO:0003677

GO:0003684

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006289

GO:0006290

GO:0006974

GO:0009411

GO:0016567

GO:0016740

GO:0030054

GO:0031464

GO:0031465

GO:0032991

GO:0034644

GO:0036211

GO:0043226

GO:0044877

GO:0051865

GO:0070914

GO:0080008

GO:0090734

GO:0140096

HMNXSV003042721

ILMN_1660817

PH_hs_0034842

TC11000404.hg

U18300_at

g4557514_3p_at

Participates

as a component of

as a member of

DCAF protein [nucleoplasm] (Homo sapiens)

as an output of

TP53 stimulates DDB2 expression (Homo sapiens)

Other forms of this molecule

PolyUb-DDB2 [nucleoplasm]

PAR-DDB2 [nucleoplasm]

Inferred To

Ddb2 [nucleoplasm] (Mus musculus)

Ddb2 [nucleoplasm] (Rattus norvegicus)

DDB2 [nucleoplasm] (Bos taurus)

DDB2 [nucleoplasm] (Canis familiaris)

DDB2 [nucleoplasm] (Gallus gallus)

DDB2 [nucleoplasm] (Sus scrofa)

Ghost homologue of DDB2 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of DDB2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of DDB2 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of DDB2 [nucleoplasm] (Plasmodium falciparum)

ddb2 [nucleoplasm] (Danio rerio)

ddb2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001287663.1, NP_000098.1

OpenTargets

ENSG00000134574

HPA

ENSG00000134574-DDB2

GeneCards

Q92466

Ensembl

ENSP00000256996, ENST00000616278, ENST00000378600, ENSP00000367863, ENSP00000478411, ENSP00000367866, ENST00000256996, ENSP00000367864, ENSG00000134574, ENST00000378603, ENST00000378601

PRO

Q92466

Pharos - Targets

Q92466

Orphanet

15855

HMDB Protein

HMDBP10931

PDB

6R90, 4E54, 3EI4, 6R92, 4E5Z, 6R91, 6R8Z, 3I7L, 6R8Y

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.967	23
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.886	12
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.837	10
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.788	12
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.725	8
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.643	5
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.643	5
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.643	4
UniProt:Q9BW61 DDA1	1	DDA1 [nucleoplasm] (R-HSA-8863297)	0.643	3
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.643	3
UniProt:Q9BT78 COPS4	2	COPS4 [nucleoplasm] (R-HSA-5697020) COPS4 [cytosol] (R-HSA-416965)	0.643	4
UniProt:Q01831-1 XPC			0.576	4
UniProt:Q3U1J4	1	Ddb1 [nucleoplasm] (R-MMU-53489)	0.564	2
UniProt:P40337-2 VHL			0.556	3
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.544	2
UniProt:Q6B0B8 TIGD3			0.527	2
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.527	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	2
UniProt:Q08830 FGL1			0.527	2
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.527	3
UniProt:O60232 ZNRD2			0.527	3
UniProt:Q8NBX0 SCCPDH	2	SCCPDH [extracellular region] (R-HSA-8862997) SCCPDH [platelet alpha granule lumen] (R-HSA-8862982)	0.527	3
UniProt:Q99627 COPS8	2	COPS8 [cytosol] (R-HSA-416962) COPS8 [nucleoplasm] (R-HSA-5697014)	0.527	3
UniProt:Q9H9Q2 COPS7B	2	COPS7B [cytosol] (R-HSA-416966) COPS7B [nucleoplasm] (R-HSA-5697023)	0.527	3
UniProt:Q9UBZ4 APEX2			0.527	2
UniProt:Q9NQP4 PFDN4	1	PFDN4 [cytosol] (R-HSA-379542)	0.527	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	3
UniProt:Q9NYZ3 GTSE1	4	GTSE1 [cytosol] (R-HSA-8852264) p-S435-GTSE1 [cytosol] (R-HSA-8852316) p-S435-GTSE1 [nucleoplasm] (R-HSA-8852332) p-T513,T526-GTSE1 [cytosol] (R-HSA-8852308)	0.527	2
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.527	3
UniProt:P53673 CRBA4			0.527	3
UniProt:Q9NWH7 SPAT6			0.499	2

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